Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Klionsky,, Daniel J., A. P., Giulia And, A., Ravi K., A. B., Eric H., A. B., Andrea And, B., Patricia And Bravo-San, P., Jose Manuel And, C., Ken,, Cecconi, F., Choi,, Augustine M. K., A. C., Mary E., A. C., Charleen T., A. C., Patrice And, C., Maria Isabel And, C., Ana Maria And, D., Vojo And, D., Ivan And, E., Zvulun And, E., Eeva-Liisa And, F., Gian Maria And, G., David A., A. G., Douglas R., A. H., Malene And, J., Marja And, J., Terje And, J., Gabor And, K., Vassiliki And, K., Claudine And, K., Guido And, K., Nicholas T., A. K., Sharad And, L., Carlos And, M., Kay F., A. M., Frank And, M., Jennifer And, M., Alicia And, M., Noboru And, M., Christian And, P., Josef M., A. P., Rushika M., A. P., Mauro And, R., Fulvio And, R., David C., A. R., Kevin M., A. S., Junichi And, S., Laura And, S., Luca And, S., Hans-Uwe And, S., Anna Katharina And, S., Anne And, S., Alexandra And, T., Nektarios And, T., Sharon A., A. Y., Tamotsu And, Y., Junying And, Y., Zhenyu And, Z., Qing And, G., Lorenzo And, P., Federico, Autophagy in major human diseases, <<EMBO JOURNAL>>, 2021; 40 (19): N/A-N/A. [doi:10.15252/embj.2021108863] [https://hdl.handle.net/10807/302261]
Autophagy in major human diseases
Cecconi, Francesco;
2021
Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.File | Dimensione | Formato | |
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