Autophagy in major human diseases

Klionsky,; and Petroni, Daniel J.; Giulia and Amaravadi,; and Baehrecke, Ravi K.; and Ballabio, Eric H.; Andrea and Boya,; Patricia and Bravo-San Pedro,; Jose Manuel and Cadwell,; Ken,; Cecconi, Francesco; Choi,; and Choi, Augustine M. K.; and Chu, Mary E.; and Codogno, Charleen T.; Patrice and Colombo,; Maria Isabel and Cuervo,; Ana Maria and Deretic,; Vojo and Dikic,; Ivan and Elazar,; Zvulun and Eskelinen,; Eeva-Liisa and Fimia,; Gian Maria and Gewirtz,; and Green, David A.; and Hansen, Douglas R.; Malene and Jaattela,; Marja and Johansen,; Terje and Juhasz,; Gabor and Karantza,; Vassiliki and Kraft,; Claudine and Kroemer,; Guido and Ktistakis,; and Kumar, Nicholas T.; Sharad and Lopez-Otin,; Carlos and Macleod,; and Madeo, Kay F.; Frank and Martinez,; Jennifer and Melendez,; Alicia and Mizushima,; Noboru and Munz,; Christian and Penninger,; and Perera, Josef M.; and Piacentini, Rushika M.; Mauro and Reggiori,; Fulvio and Rubinsztein,; and Ryan, David C.; and Sadoshima, Kevin M.; Junichi and Santambrogio,; Laura and Scorrano,; Luca and Simon,; Hans-Uwe and Simon,; Anna Katharina and Simonsen,; Anne and Stolz,; Alexandra and Tavernarakis,; Nektarios and Tooze,; and Yoshimori, Sharon A.; Tamotsu and Yuan,; Junying and Yue,; Zhenyu and Zhong,; Qing and Galluzzi,; Lorenzo and Pietrocola,; Federico,

doi:10.15252/embj.2021108863

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Klionsky,, Daniel J., A. P., Giulia And, A., Ravi K., A. B., Eric H., A. B., Andrea And, B., Patricia And Bravo-San, P., Jose Manuel And, C., Ken,, Cecconi, F., Choi,, Augustine M. K., A. C., Mary E., A. C., Charleen T., A. C., Patrice And, C., Maria Isabel And, C., Ana Maria And, D., Vojo And, D., Ivan And, E., Zvulun And, E., Eeva-Liisa And, F., Gian Maria And, G., David A., A. G., Douglas R., A. H., Malene And, J., Marja And, J., Terje And, J., Gabor And, K., Vassiliki And, K., Claudine And, K., Guido And, K., Nicholas T., A. K., Sharad And, L., Carlos And, M., Kay F., A. M., Frank And, M., Jennifer And, M., Alicia And, M., Noboru And, M., Christian And, P., Josef M., A. P., Rushika M., A. P., Mauro And, R., Fulvio And, R., David C., A. R., Kevin M., A. S., Junichi And, S., Laura And, S., Luca And, S., Hans-Uwe And, S., Anna Katharina And, S., Anne And, S., Alexandra And, T., Nektarios And, T., Sharon A., A. Y., Tamotsu And, Y., Junying And, Y., Zhenyu And, Z., Qing And, G., Lorenzo And, P., Federico, Autophagy in major human diseases, <<EMBO JOURNAL>>, 2021; 40 (19): N/A-N/A. [doi:10.15252/embj.2021108863] [https://hdl.handle.net/10807/302261]