We investigated the association between 157 SNPs located in 75 candidate genes involved in the immune system and proxy traits for resistance to gastrointestinal nematodes in sheep. A total of 211 lambs from eight flocks were sampled. Nematode eggs per gram were counted and classified as: (i) Strongyles, (ii) Nematodirus spp., (iii) Trichuris spp. and (iv) Marshallagia marshalli. Single- and multiple-locus models were used to test the marker–trait associations. Seven significant SNPs were identified on chromosomes OAR6, 15, 16, and 19. These findings provide insights for breeding nemarode-resistant traits in low-input production systems. General linear model, fixed and random model circulating probability unification, and Bayesian-information and linkage-disequilibrium iteratively nested keyway analyses identified a significant association between the eggs per gram of Strongyles nematodes and a specific variant of the PRLR gene.

Rafat, S. A., Barbato, M., Hajializadehvalilou, R., Moghaddam, G. H., Nematollahi, A., Periasamy, K., Pichler, R., Ajmone Marsan, P., Identification of genomic regions associated with resistance to gastrointestinal parasites in an indigenous sheep by single- and multiple-locus methods, <<ANIMAL GENETICS>>, 2024; 55 (2): 286-290. [doi:10.1111/age.13392] [https://hdl.handle.net/10807/301080]

Identification of genomic regions associated with resistance to gastrointestinal parasites in an indigenous sheep by single- and multiple-locus methods

Ajmone Marsan, Paolo
2024

Abstract

We investigated the association between 157 SNPs located in 75 candidate genes involved in the immune system and proxy traits for resistance to gastrointestinal nematodes in sheep. A total of 211 lambs from eight flocks were sampled. Nematode eggs per gram were counted and classified as: (i) Strongyles, (ii) Nematodirus spp., (iii) Trichuris spp. and (iv) Marshallagia marshalli. Single- and multiple-locus models were used to test the marker–trait associations. Seven significant SNPs were identified on chromosomes OAR6, 15, 16, and 19. These findings provide insights for breeding nemarode-resistant traits in low-input production systems. General linear model, fixed and random model circulating probability unification, and Bayesian-information and linkage-disequilibrium iteratively nested keyway analyses identified a significant association between the eggs per gram of Strongyles nematodes and a specific variant of the PRLR gene.
2024
Inglese
Rafat, S. A., Barbato, M., Hajializadehvalilou, R., Moghaddam, G. H., Nematollahi, A., Periasamy, K., Pichler, R., Ajmone Marsan, P., Identification of genomic regions associated with resistance to gastrointestinal parasites in an indigenous sheep by single- and multiple-locus methods, <<ANIMAL GENETICS>>, 2024; 55 (2): 286-290. [doi:10.1111/age.13392] [https://hdl.handle.net/10807/301080]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/301080
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