Reconstruction Techniques and Associated Morbidity in Minimally Invasive Gastrectomy for Cancer Insights From the GastroBenchmark and GASTRODATA databases

Schneider, M. A.; Kim, J.; Berlth, F.; Sugita, Y.; Grimminger, P. P.; Wijnhoven, B. P. L.; Overtoom, H.; Gockel, I.; Thieme, R.; Griffiths, E. A.; Butterworth, W.; Nienhuser, H.; Muller, B.; Crnovrsanin, N.; Gero, D.; Nickel, F.; Gisbertz, S.; van Berge Henegouwen, M. I.; Pucher, P. H.; Khan, K.; Chaudry, A.; Patel, P. H.; Pera, M.; Dal Cero, M.; Garcia, C.; Salinas, G. M.; Kassab, P.; Castro, O. A. P.; Norero, E.; Wisniowski, P.; Putnam, L. R.; Lombardi, P. M.; Ferrari, G.; Gudaityte, R.; Maleckas, A.; Prodehl, L.; Castaldi, A.; Prudhomme, M.; Lee, H. -J.; Sano, T.; Baiocchi, G. L.; De Manzoni, G.; Giacopuzzi, S.; Bencivenga, M.; Rosati, R.; Puccetti, F.; D'Ugo, Domenico; Nunobe, S.; Yang, H. -K.; Gutschow, C. A.; Piessen, G.; Lerooy, J.; van Sandick, J. W.; Reynolds, J. V.; Morgagni, P.; Holscher, A. H.; Hemmerich, M.; Monig, S.; Chevallay, M.; Kolodziejczyk, P.; Hartgrink, H.; da Costa, P. M.; Borges, F. C.; de Medicina, F.; Davies, A.; Baker, C.; Allum, W.; Kumar, S.; Polkowski, W.; Rawicz-Pruszynski, K.; Romario, U. F.; De Pascale, S.; Tarasconi, A.; Reim, D.; Pergolini, I.; Santos, L. L.; Martins, P. C.; Biondi, Alberto; Degiuli, M.; Reddavid, R.; Kielan, W.; Schneider, P. M.; Murphy, T.

doi:10.1097/SLA.0000000000006470

Objective/Background: Various anastomotic and reconstruction techniques are used for minimally invasive total (miTG) and distal gastrectomy (miDG). Their effects on postoperative morbidity have not been extensively studied. Methods: MiTG and miDG patients were selected from 9356 oncological gastrectomies performed in 2017–2021 in 43 centers. Endpoints included anastomotic leakage (AL) rate and postoperative morbidity tested by multivariable analysis. Results: Three major anastomotic techniques [circular stapled (CS); linear stapled (LS); and hand sewn (HS)], and 3 major bowel reconstruction types [Roux (RX); Billroth I (BI); Billroth II (BII)] were identified in miTG (n = 878) and miDG (n = 3334). Postoperative complications, including AL (5.2% vs 1.1%), overall (28.7% vs 16.3%), and major morbidity (15.7% vs 8.2%), as well as 90-day mortality (1.6% vs 0.5%) were higher after miTG compared with miDG. After miTG, the AL rate was higher after CS (4.3%) and HS (7.9%) compared with LS (3.4%). Similarly, major complications (LS: 9.7%, CS: 16.2%, and HS: 12.7%) were lowest after LS. Multivariate analysis confirmed anastomotic technique as a predictive factor for AL, overall, and major complications. In miDG, AL rate (BI: 1.4%, BII 0.8%, and RX 1.2%), overall (BI: 14.5%, BII: 15.0%, and RX: 18.7%), and major morbidity (BI: 7.9%, BII: 9.1%, and RX: 7.2%), and mortality (BI: 0%, BII: 0.1%, and RY: 1.1%%) were not affected by bowel reconstruction. Conclusions: In oncologically suitable situations, miDG should be preferred to miTG, as postoperative morbidity is significantly lower. LS should be a preferred anastomotic technique for miTG in Western Centers. Conversely, bowel reconstruction in DG may be chosen according to the surgeon’s preference.

Schneider, M. A., Kim, J., Berlth, F., Sugita, Y., Grimminger, P. P., Wijnhoven, B. P. L., Overtoom, H., Gockel, I., Thieme, R., Griffiths, E. A., Butterworth, W., Nienhuser, H., Muller, B., Crnovrsanin, N., Gero, D., Nickel, F., Gisbertz, S., Van Berge Henegouwen, M. I., Pucher, P. H., Khan, K., Chaudry, A., Patel, P. H., Pera, M., Dal Cero, M., Garcia, C., Salinas, G. M., Kassab, P., Castro, O. A. P., Norero, E., Wisniowski, P., Putnam, L. R., Lombardi, P. M., Ferrari, G., Gudaityte, R., Maleckas, A., Prodehl, L., Castaldi, A., Prudhomme, M., Lee, H. -., Sano, T., Baiocchi, G. L., De Manzoni, G., Giacopuzzi, S., Bencivenga, M., Rosati, R., Puccetti, F., D'Ugo, D., Nunobe, S., Yang, H. -., Gutschow, C. A., Piessen, G., Lerooy, J., Van Sandick, J. W., Reynolds, J. V., Morgagni, P., Holscher, A. H., Hemmerich, M., Monig, S., Chevallay, M., Kolodziejczyk, P., Hartgrink, H., Da Costa, P. M., Borges, F. C., De Medicina, F., Davies, A., Baker, C., Allum, W., Kumar, S., Polkowski, W., Rawicz-Pruszynski, K., Romario, U. F., De Pascale, S., Tarasconi, A., Reim, D., Pergolini, I., Santos, L. L., Martins, P. C., Biondi, A., Degiuli, M., Reddavid, R., Kielan, W., Schneider, P. M., Murphy, T., Reconstruction Techniques and Associated Morbidity in Minimally Invasive Gastrectomy for Cancer Insights From the GastroBenchmark and GASTRODATA databases, <<ANNALS OF SURGERY>>, 2024; 280 (5): 788-798. [doi:10.1097/SLA.0000000000006470] [https://hdl.handle.net/10807/297900]