IRIS PubliCatt

Objective: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications. Summary background data: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level. Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes. Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4,263 (19.7%), and 6,622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1,738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, ASA physical status class, surgical setting, operative approach and Nassar operative difficulty grade were identified as the five predictors demonstrating the highest relative importance in predicting postoperative complications. Conclusion: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.

Geoffrey Yuet Mun, W., Himanshu, W., Victor, R. C., Laura, B. M., Yashasvi, R., Ricardo David, M., Alessandro, M., Vignesh, B., Aabid, A., Adeela, S., Ahmad Ghassan, A., Ahmed, M. A., Ajay, G., Akram, A., Amel, O., Amira, S., Anshuman, P., Ashwani, K., Baila, M., Carlos Alberto, M., Cheena, S., Diana Alejandra, P. P., Dmitry Mikhailovich, A., Enrique, P., Fariha, A., Marco, C., Francesk, M., Gad Amram, M., Gamaleldeen, A., Georgios-Ioannis, V., Giacomo, C., Gianluigi, M., Hossam, E., Hui, L., Humam, J., Ibrahim, E., Jayanta Kumar, D., Jose Miguel, A., Kazi T, A., Luca, D., Manisha, A., Mohammed Ahmed, O., Mounira, R., Muhammed, E., Nasser, S., Rajesh, B., Ramesh, A., Samir, K., Sarnai, E., Serge, C., Suhail, K., Surrendar, D., Syed Tanseer, A., Tak Kwan James, F., Taryel, O., Valentin Titus, G., Zdenko, B., Georgios, V. G., Rishi, S., Kamal, M., Madhok, B., Graham, Y., Donohoe, C., Reira, M., Wadhawan, H., Vish, Y., Jain, R., Elhadi, M., Popat, S., Boddy, A., Jain, V., Singhal, R., Mahawar, K., Martinino, A., Said, A., Neves Marques, C., Wazir, I., Pablo Scarano Pereira, J., Abouelazayem, M., Viswanath, N., Sarodaya, V., Bala, V., Homayoon, R., Dogjani, A., Tidjane, A., Antozzi, L., Hong, J., Omarov, T., Kanti Dash, A., Chokshi, A., Ricardo Wietzycoski, C., Petkov, P., Claude Mbonicura, J., Yang, W., Zuluaga, M., Kraljik, D., P Lincango Naranjo, E., Mohamed Elghadban, H., Diaz, A., Gerogiannis, I., Mohammed, A., Lazaros, L., Mulita, F., Govil Bhasker, A., Kermansaravi, M., Salah Mahdi, A., Yasser Kayyal, M., Sakran, N., Frattini, F., Bilal Alabdallah, N., Ronoh Sylvester, K., Abdelhamid, I., Hayssam El Fawal, M., Nuri Allawgalli, A., Dulskas, A., Voon, K., Caruana, C., Ponce De Leon Ballesteros, G., Erdene, S., Ouadii, M., Abdulrashid Nashidengo, P., Hazebroek, E., Gunawardene, A., Adeyeye, A., H Shariff, A., Juan Liakopulos, N., J Toro-Huamanchumo, C., Waledziak, M., Borges, N., Shabbir, A., Negoi, I., Neimark, A., Abouleid, A., Kim, G., Aleš Košir, J., Ruiz Úcar, E., S Hamid, H. K., Masri, R., Ozmen, M., Taha, S., Goodman, E., Al-Naggar, H., Khayreddine Ghouali, A., Wafa, B., Allel, S., Mohamed Elkacem, B., Ibagherache, R., Ouyahia, A., Rais, M., Hachemi Seddik, E., Tinhinane Kouicem, A., Abdoun, M., Bouaoud, S., Boucenak, K., Khalfa, S., Brahim, B., Tidjane, A., Tabeti, B., Meharzi, S., Larbi, H., Derdous, R., Abderaouf, B., Bouregba, N., Boukaaabeche, F., Djeroua, K., Ali Sabrin, N., Khennaf, L., Nabil Mesli, S., Khayreddine Ghouali, A., Aissat, A., Alejandra Pantoja Pachajoa, D., Andrés Alvarez, F., Benitez Milagros, N., Cecilia Medrano Ortiz Palombarini, V., Petracchi, E., Quesada, M., Canullan, C., Varela, J., Posada, H., Du Plessis, C., Ignacio Valenzuela, J., Andrea Fernandez Zurita, M., Nasim, S., Alexander Bowles, T., Yeboah, E., Nair, R., Moritz Felsenreich, D., Omarov, T., Allahverdiyeva, N., Abizade, R., Mikhailovich Adamovich, D., Alvim Barreiro, T., Azevedo De Vasconcelos Cunha, H., Victor Castilho, M., Meneguzzi Alves Ferreira, R., Legati 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Degrate, L., Konadu Adjei Antwi, S., Brisinda, G., Fico, V., Mirco, P., Biondi, A., Persiani, R., Giovinazzo, F., Frongillo, F., Evola, G., Ferrara, F., Altomare, M., Benuzzi, L., Pezzoli, I., Borghi, A., Cimbanassi, S., Dapri, G., Nessi, C., Bianco, F., Margherita Letizia Uccelli, F., Viganò, L., Cordaro, G., Dionigi, G., Pino, A., Morezzi, D., Rizzo, R., Convertini, G., Vallicelli, C., Catena, F., Verdi, D., Mondi, I., Da Lio, C., Loss, G., D'Acapito, F., Di Pietrantonio, D., Tauceri, F., Ercolani, G., Bottino, V., Bosco, A., Canfora, A., Chiappetta, S., Frattini, F., Rizzi, A., Breda, M., Quaglino, F., Festa, F., Maria Chiara Savasta, F., Fiore, A., Soncini, S., Giordano, A., Carganico, G., Cocchi, L., Epis, L., Moretto, G., Casaril, A., Inama, M., Harmony, I., Michail, C., Alessandro, V., Piazza, M., Basile, G., Pinotti, E., Lapolla, P., Mingoli, A., Brachini, G., Cirillo, B., Campanelli, M., Gentileschi, P., Rossi, S., Picardi, B., Savia, E., Olmi, S., Uccelli, M., Balla, A., Lepiane, P., Saraceno, F., Coppola, A., Clementi, M., Paniccia, F., Grasso, A., Tartaglia, N., Pavone, G., Ambrosi, A., Angelico, R., Maria Manzia, T., Materazzo, M., Tisone, G., Calini, G., Bresadola, V., Morinelli, V., Matucci-Cerinic, P., Michelutti, L., Luzzi, A., Romairone, E., Carrabetta, S., Marzorati, S., Khamees, A., Meizer Mohammad, A., Alananzeh, S., Al Momani, S., Hijazin, N., Abdulhadi Tarawneh, S., Alheji, H., Alhajji, A., Ghassan Al-Shkirat, A., N Alzoubi, M., Rahman Abdullah Al Manasra, A., Elayyan, R., Jamous, H., Dardour, M., Rawhi Mahafdah, M., Ahmad Al Hammoud, A., Al Quran, M., Bosire, F., Magdy Zakaria, R., Reda Abdullah, H., Tarboush, A., Abraheem Hasan, W., Abdulnasir Kredan, A., Zreeg, D., Muftah, A., Koshlaf, A., Albadi, D., Omar Abunaaja, H., Otman, R., Ben Hamida, B., Gamal Amnaina, M., Faraj Alhaddad, H., Musbah Shuaip, N., Buderbala, Y., Faraj Hamad, A., Shames, H., Bileid Bakeer, H., Alkaseek, A., Esnoussi Shalabi, L., Salih Alhadi, A., A Ahjaaz, M. A., Zgheel, U., Abdulmoula, Z., Younis, H., Khayri Aboubeirah, M., Hassan Binnawara, M., Abdusslam Arebi, J., Ali Alboueishi, A., Mohammed Ammar, S., Abdedalmajed Rhuma, H., Alsori Alharari, M., Emhemmed Endisha, S., E'Ng Ng, C., Wei Lee, Y., Zhir Tay, Y., Abdul Manan, N., Syazwan Tajul Arifin, M., Solihin Khairul Anuar, A., Kumar, N., Kumar Maiyauen, T., Dzulkarnaen Zakari, A., Azem Fathi, M., Izzati Izhar, M., Azzyati Awang Dahlan, D., Mokhtar, S., Samsudin, S., Singh Jaktaram Singh, B., Pillai Arumugam, M., Krishnasamy, T., Amir Manap, S., Woon Yong, C., Nazri Mohamed Nabil, M., Sze Huey Lim, J., Voon, K., Yu Cheng, S., Mubarak Amanullah, M., Ahmed, N., Vern Lim, I., Rashid Mazlan, M., Sivananthan, A., Yussra, Y., Nathan Puvisny, S., Bin Chua, I., Sharman, M., Li Siow, S., Axiak, J., Dowling, J., Portelli, M., Caruana, C., Beristain-Hernandez, J., Vazquez-Romero, O., Jaime-Silva, J., Cadena-Guzman, J., Miguel Aceves-Ayala, J., Marielena Treviño-Meza, J., Efrain-Sosa-Duran, E., Rafael Guzman-Águilar, M., Edusrdo Zuñiga, J., Manuel Pinto Angulo, V., Trejo-Avila, M., Bozada-Gutierrez, K., Carrion, C., Norma Gómez-Herrera, M., García-Gómez, A., Arnulfo Pimentel Melendez, S., Olaf Bautista Martinez, A., Nuñez De La Rosa, S., Inchaustegui Tinajero, J., Ervey Sordo Lima, D., Humberto Pérez-Soto, R., David Hernández-Acevedo, J., Domínguez-Rosado, I., Ángel Mercado-Díaz, M., Sierra-Salazar, M., Pimienta, A., Erdene, S., Sandag, E., Orgoi, S., Ochir, C., Batmunkh, M., Ouazzani, E., El Fdili, M., Hassani Ibn Majdoub, K., Mazaz, K., Errachidy, M., Mekondjo Nashidengo, P., William Quayson, F., Tabiri Abebrese, J., Sushmita Seibes, S., Tjipetekera, R., Lim, Y., Haimona, M., F Mcclean, S., Eddylena Gutierrez Rodriguez Rodriguez, S., Arnoldo Arauz Lopez Lopez, A., Adetoyese Adeyeye, A., Stanley Nwabuoku, E., Mohammed Bello, U., Musa Umar, B., Godfrey Makama, J., Aminu, B., Nehiweze Oriakhi, S., Obi Mosanya, A., Ehidiamen Omon, H., Olanike Wuraola, F., Ishola, A., Ulasi, I., O Irowa, O., I Agbonrofo, P., Irmiya, S., Siddique Ammar, A., Khattak, S., Qureshi, S., Wahid Bashir, N., Jalal, H., Kamran, A., Sultan, R., Fatima, M., Janjua, A., Farooq, O., Taha Junaid Khan, M., Soomro, U., Saleem, A., Ahmed Khawaja, U., Seth Martins, R., Dawani, S., Siddiqui, A., Masood Khan, M., Jafferi, S., Qaiser Faizi, T., Talib, V., Ali, D., Hassan Javed, M., Ahsan Rasheed, M., Mughal, J., Ijaz, N., Ur Rehman, I., Aurangzeb, M., Ahmed, N., Ullah Jan, Z., Khan, S., Saeed Aziz, S., Ghazala Shamim Afridi, S., Asad Maroof, S., Imaran Khan, M., Zarin, M., Naz, F., Jan, Z., Tanseer Asghar, S., Ali, S., Azam, S., Jalil, H., Naqvi, H., Ashraf, F., Siddiqui, T., Murataza, G., Bari, H., Ahmed, H., Abu Jayyab, M., Al-Dahdouh, M., Rainer Echeverria, R., Ynoue Mendoza, M., Kisielewski, M., Stefura, T., Richter, K., Klos, N., Walędziak, M., Bartosiak, K., Komorowska, K., Trigo Silvestre, M., Santos, C., Gil, I., Silva Cardoso, V., Rocha Melo, M., Lima, R., Bolota, J., Cotovio, M., Titus Grigorean, V., Rares Stoian, A., Diana Andreea, D., A Toma, E., Lunca, S., Zarnescu, N., Virgil Costea, R., Litvin, A., Aljohani, E., Zaid, A., Shaar, K., Awaf, K., Zakarneh, E., Alowayrdi, T., Alyami, F., Alamer, A., Y Taha, M., Chowdhury, S., Alshahrani, S., Panyko, A., Aleš Košir, J., Grosek, J., Tomažič, A., Pintar, T., Ruiz Úcar, E., Castro, E., Sambrano, D., Garcia-Dominguez, R., Tusa, C., Landaluce-Olavarria, A., Estraviz-Mateos, B., González, J., Roca, B., Jayarajah, U., Subasinghe, D., Sivaganesh, S., S Hamid, H. K., Galal-Eldin, S., Eldirdiri, S., Elnour, M., Asaad, N., Mohammed, M., Saifaldawla Hassan, L., Osman Mohamed, K., Ahmed Abdelrahman, S., Alsadeg, H., Altigani Elhadi Ali, A., Abdalla Elsiddig Musa, R., Sarih, M., Ismail, S., Albasher Almaki Ahmed, O., Taj Eldeen Hassan Taj Eldeen, S., Elzaki Elsiddig, K., Elghazali Ahmed Basheer Elhasan, M., F Karamelghani, M. A., Mohammed, O., Altayeb Adam, A., Osman Barakat, H., Elnoman Elhadi, R., Abdalmajid Alnaji, A., Hamza Abdel Ghani Mohamed, E., Al Houri, H., Alhouri, A., Khmeis Soliman, A., Al Ahmad, M., Amir Kayali, A., Nasani, M., Nerabani, Y., Ashkar, E., Nabhan Sawas, M., N Aldirani, A., Zahreddin, A., M Alasmar, A., Hasan, L., Alahmed Alhosen, M., Klib, M., Rahman Hammadieh, A., Tarek Chikh Salem, M., Ghandour, M., Sara, S., Kara Tahhan, N., Albani, N., Alsaid, B., Ahmad, B., Almaydaani, M., Abbas, M., Nanaa, M., Aloulou, M., Kudra Danial, A., Khaled, A., Latouf, R., Saeed, D., Ghazal, A., Masri, R., Hamdan, O., Ayoub, K., Kadoura, L., Alazeez Atli, A., Zayat, H., Niazi, A., Dabbit, A., Dahrouj, W., Alhaj, A., Dabbagh, E., Aldaher, M., Bsata, A., Zaher Shahrour, M., Akram Khusruf, M., Wali, T., Tayeb Aldroubi, M., Badr Almoshantaf, M., Abdullah Alahmad, M., Jamil, L., Al-Nokta, A., Bakri, A., Yamen Arnaout, A., Ibrahim, H., Nastah, S., Kanaan, S., Rasheed, O., Mohammad, A., Bokal, Z., Gafsi, B., Baccar, M., Ammar, H., Ermis, I., Tokocin, M., Ahmet Kabuli, H., Tokocin, O., Ergenç, M., Gülşen, T., Erginöz, E., Sezgin Uludağ, S., Övül Bozkir, H., Zengin, K., Faik Özçelik, M., Zarbaliyev, E., Çağlikülekçi, M., Böler, D., Vartanoglu Aktokmakyan, T., Peksen, C., Anil Savas, O., Sumer, A., Emir Guldogan, C., Ozmen, M., Kaplan, M., Colak, E., Necati Şanli, A., Ibrahim Kilani, A., Kamer, E., Namdaroglu, O., Ahmed, F., Marzouk, A., Harbinson, D., Abdulrahman, H., Ali, H., Abousamra, M., Di Maggio, F., Abushawaly, A., Badawi, M., Rahman, A., Jenner, D., Said, A., Ahmed, K., Watali, Y., Soggiu, F., Sheth, H., Drymousis, P., Caterson, J., Mehmood, S., Wadhawan, H., Strachan, D., Mcelroy, L., Chauhan, M., Morgan, R., Mamun, M., Tora, M., Shamali, A., Ml Williamson, J., Slim, N., Mark, S., Huppler, L., Crane, S., Mcgrath, P., Tak Kwan Fung, J., Yan Kok, S., Bond-Smith, G., Dawani, A., Shamardal, A., M Madi Ahmed, M., Obasi, C., Gala, T., Mohammed Elshaer, A., Warner, S., Nathadwarawala, P., Askari, A., Pandanaboyana, S., Thakkar, R., Barbour, F., Guy Finch, J., Habib, H., Ansong, E., Attard, J., Aujayeb, A., Gupta, A., Fale, M., Gupta, A., Gajdhar, A., Fareed, K., Abdelfattah Elfeky, M., Ashry, M., Kaur, M., Faycal Mirghani, S., Tanveer, Y., Albendary, M., Bhattacharya, P., Abdulaal, G., Ali Ghufran, M., Ghanem, A., Leong, D., Mamidanna, R., Aamery, A., Tewari, N., Williams, G., Tariq, H., Kaur Klair, A., Jones, K., Selvachandran, H., Day, A., Ajmani, A., Parmar, C., Bosch, K., Young, R., Chan, A., Silva, Y., Kureci, A., Paranyak, M., Shepetko-Dombrovskii, O., Chooklin, S., Chuklin, S., Dutka, Y., Maqbool, B., Abdullah Gill, A., Jan, A., Murali, T., Alhajami, F., Atiah, N., Nadeesh, A., Almaqdi, S., 30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study, <<ANNALS OF SURGERY>>, 2024; (N/A): N/A-N/A. [doi:10.1097/SLA.0000000000006236] [https://hdl.handle.net/10807/297696]

30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study

Brisinda, Giuseppe;Biondi, Alberto;Persiani, Roberto;
2024

Abstract

Objective: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications. Summary background data: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level. Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes. Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4,263 (19.7%), and 6,622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1,738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, ASA physical status class, surgical setting, operative approach and Nassar operative difficulty grade were identified as the five predictors demonstrating the highest relative importance in predicting postoperative complications. Conclusion: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.
2024
Inglese
ANNALS OF SURGERY
Geoffrey Yuet Mun, W., Himanshu, W., Victor, R. C., Laura, B. M., Yashasvi, R., Ricardo David, M., Alessandro, M., Vignesh, B., Aabid, A., Adeela, S., Ahmad Ghassan, A., Ahmed, M. A., Ajay, G., Akram, A., Amel, O., Amira, S., Anshuman, P., Ashwani, K., Baila, M., Carlos Alberto, M., Cheena, S., Diana Alejandra, P. P., Dmitry Mikhailovich, A., Enrique, P., Fariha, A., Marco, C., Francesk, M., Gad Amram, M., Gamaleldeen, A., Georgios-Ioannis, V., Giacomo, C., Gianluigi, M., Hossam, E., Hui, L., Humam, J., Ibrahim, E., Jayanta Kumar, D., Jose Miguel, A., Kazi T, A., Luca, D., Manisha, A., Mohammed Ahmed, O., Mounira, R., Muhammed, E., Nasser, S., Rajesh, B., Ramesh, A., Samir, K., Sarnai, E., Serge, C., Suhail, K., Surrendar, D., Syed Tanseer, A., Tak Kwan James, F., Taryel, O., Valentin Titus, G., Zdenko, B., Georgios, V. 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[doi:10.1097/SLA.0000000000006236] [https://hdl.handle.net/10807/297696]
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