Previous studies have been inconclusive whether dominant resting state alpha rhythms are greater or lower in amplitude in subjects with Down syndrome (DS) when compared to control subjects, ample resting alpha rhythms being considered as a reflection of good mechanisms of cortical neural synchronization. Here we tested the hypothesis that when the effects of head volume conduction are taken into account by the normalization of the cortical sources of resting alpha rhythms, these sources are lower in amplitude in DS subjects than in controls in line with typical findings in Alzheimer's disease patients.
Babiloni, C., Albertini, G., Onorati, P., Muratori, C., Buffo, P., Condoluci, C., Sarà, M., Pistoia, F., Vecchio, F., Rossini, P. M., Cortical sources of EEG rhythms are abnormal in down syndrome, <<CLINICAL NEUROPHYSIOLOGY>>, 2010; 121 (8): 1205-1212. [doi:10.1016/j.clinph.2010.02.155] [http://hdl.handle.net/10807/29599]
Cortical sources of EEG rhythms are abnormal in down syndrome
Condoluci, Carola;Rossini, Paolo Maria
2010
Abstract
Previous studies have been inconclusive whether dominant resting state alpha rhythms are greater or lower in amplitude in subjects with Down syndrome (DS) when compared to control subjects, ample resting alpha rhythms being considered as a reflection of good mechanisms of cortical neural synchronization. Here we tested the hypothesis that when the effects of head volume conduction are taken into account by the normalization of the cortical sources of resting alpha rhythms, these sources are lower in amplitude in DS subjects than in controls in line with typical findings in Alzheimer's disease patients.
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