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INTRODUCTION:Antibiotic resistance is one of the main factors that determine the efficacy of treatments to eradicate Helicobacter pylori infection. Our aim was to evaluate the effectiveness of first-line and rescue treatments against H. pylori in Europe according to antibiotics resistance. METHODS:Prospective, multicenter, international registry on the management of H. pylori (European Registry on H. pylori Management). All infected and culture-diagnosed adult patients registered in the Spanish Association of Gastroenterology-Research Electronic Data Capture from 2013 to 2021 were included. RESULTS:A total of 2,852 naive patients with culture results were analyzed. Resistance to clarithromycin, metronidazole, and quinolones was 22%, 27%, and 18%, respectively. The most effective treatment, regardless of resistance, were the 3-in-1 single capsule with bismuth, metronidazole, and tetracycline (91%) and the quadruple with bismuth, offering optimal cure rates even in the presence of bacterial resistance to clarithromycin or metronidazole. The concomitant regimen with tinidazole achieved an eradication rate of 99% (90/91) vs 84% (90/107) with metronidazole. Triple schedules, sequential, or concomitant regimen with metronidazole did not achieve optimal results. A total of 1,118 non-naive patients were analyzed. Resistance to clarithromycin, metronidazole, and quinolones was 49%, 41%, and 24%, respectively. The 3-in-1 single capsule (87%) and the triple therapy with levofloxacin (85%) were the only ones that provided encouraging results. DISCUSSION:In regions where the antibiotic resistance rate of H. pylori is high, eradication treatment with the 3-in-1 single capsule, the quadruple with bismuth, and concomitant with tinidazole are the best options in naive patients. In non-naive patients, the 3-in-1 single capsule and the triple therapy with levofloxacin provided encouraging results.
Bujanda, L., Nyssen, O. P., Ramos, J., Bordin, D. S., Tepes, B., Perez-Aisa, A., Pavoni, M., Castro-Fernandez, M., Lerang, F., Leja, M., Rodrigo, L., Rokkas, T., Kupcinskas, J., Jonaitis, L., Shvets, O., Gasbarrini, A., Simsek, H., Phull, P. S., Buzás, G. M., Machado, J. C., Boltin, D., Boyanova, L., Tonkić, A., Marlicz,, Article: Stomach Effectiveness Of Helicobacter Pylori Treatments According To Antibiotic Resistance, B., Luis, M., Phd1,, Nyssen, O. P. P., Ramos, J. M., Bordin, D. S. M., Tepes, B. M., Perez-Aisa, A. P., Pavoni, M. M., Castro-Fernandez, M. P., Lerang, F. M., Leja, M. M., Rodrigo, L. P., Rokkas, T. P., Kupcinskas, J. M., Jonaitis, L. M., Shvets, O. M., Gasbarrini, A. P., Simsek, H. M., Phull, P. S. M., Buzás, G. M. M., Machado, J. C. M., Boltin, D. M., Boyanova, L. M., Tonkić, A. M., Marlicz, W. M., Venerito, M. M., Vologzanina, L. M., Fadieienko, G. D. M., Fiorini, G. M., Resina, E. M., Muñoz, R. M., Cano-Català, A. P., Puig, I. P., García-Morales, N. M., Hernández, L. M., Moreira, L. P., Megraud, F. P., Morain, C. O. P., Montes, M. P. P., Gisbert, J. P. P., Collaborators Fiorinni, G., Saracino, I. M., Pabon Carrasco, M., Keco Huerga, A., Alfaro Almajano, E., Martinez Dominguez, S. J., Alonso Galan, H., Velayos, B., Dueñas Sadornil, C., Botargues Bote, J. M., Gonzalez-Cordero, P. L., Areia, M., Gomez Rodriguez, B. J., Pellicano, R., Nuñez, Ó., Franceschi, F., Alekseenko, S., Perona, M., Abdulkhakov, R., Dominguez-Cajal, M., Almela Notari, P., Gomez Camarero, J., Jimenez Moreno, M., Algaba, A., Bermejo, F., Tejedor Tejada, J., Oblitas Susanibar, E., Boltin, D., Georgopoulos, S., Omorain, C., Qasim, A., Beales, I., Bakulina, N., Fadeenko, G., Malfertheiner, P., Rosania, R., Ilchishina, T., Bogomolov, P., Bakulin, I., Zaytsev, O., Gravina, A. G., Romano, M., Di Leo, A., Losurdo, G., Grigorieva, L., Delgado Guillena, P., Marusic, M., Jurcic, D., Dekhnich, N. N., Iyo, E., De La Peña Negro, L. C., Baryshnikova, N., Bakanova, N., Simsek, H., Simsek, C., Gridnyev, O., Fernandez-Bermejo, M., Angueira, T., Ruiz-Zorrilla Lopez, R., Gomez, B., Kovacheva-Slavova, M., Lahat, A., Alcedo, J., Campillo, A., Nikolaevna Belousova, L., Pajares Villarroya, R., Ljubicic, N., Nikolic, M., González-Santiago, J. M., Santamaría, D. B., Pakhomova, A., Sekulic-Spasic, I., Ghisa, M., Farinati, F., Sagdati, S. I., Panic, N., Heluwaert, F., Amorena, E., Moreira, L., Fernandez Esparrach, G., Yuryevna Plotnikova, E., Kukla, M., Kamburov, V., Lamuela Calvo, L. J., Rankovic, I., Cuadrado Lavín, A., Arguedas Lazaro, Y., Gonzalez Carrera, V., Dobrowolska, A., Eder, P., Kononova, A., Venerito, M., Vologzanina, L., Fadieienko, G. D., Fiorini, G., Resina, E., Muñoz, R., Cano-Català, A., Puig, I., García-Morales, N., Hernández, L., Moreira, L., Megraud, F., Morain, C. O., Montes, M., Gisbert, J. P., Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance, <<THE AMERICAN JOURNAL OF GASTROENTEROLOGY>>, N/A; 119 (4): N/A-N/A. [doi:10.14309/ajg.0000000000002600] [https://hdl.handle.net/10807/292158]
Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance
Bujanda, Luis;Nyssen, Olga P;Ramos, June;Bordin, Dmitry S;Tepes, Bojan;Perez-Aisa, Angeles;Pavoni, Matteo;Castro-Fernandez, Manuel;Lerang, Frode;Leja, Mārcis;Rodrigo, Luis;Rokkas, Theodore;Kupcinskas, Juozas;Jonaitis, Laimas;Shvets, Oleg;Gasbarrini, Antonio;Simsek, Halis;Phull, Perminder S;Buzás, György Miklós;Machado, Jose C;Boltin, Doron;Boyanova, Lyudmila;Tonkić, Ante;Marlicz;ARTICLE: STOMACH Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance Bujanda;Luis MD;PhD1;Nyssen, Olga P. PhD2;Ramos, June MD1;Bordin, Dmitry S. MD3;Tepes, Bojan MD4;Perez-Aisa, Angeles PhD5;Pavoni, Matteo MD6;Castro-Fernandez, Manuel PhD7;Lerang, Frode MD8;Leja, Mārcis MD9;Rodrigo, Luis PhD10;Rokkas, Theodore PhD11;Kupcinskas, Juozas MD12;Jonaitis, Laimas MD12;Shvets, Oleg MD13;Gasbarrini, Antonio PhD14;Simsek, Halis MD15;Phull, Perminder S. MD16;Buzás, György Miklós MD17;Machado, Jose C. MD18;Boltin, Doron MD19;Boyanova, Lyudmila MD20;Tonkić, Ante MD21;Marlicz, Wojciech MD22;Venerito, Marino MD23;Vologzanina, Ludmila MD24;Fadieienko, Galina D. MD25;Fiorini, Giulia MD6;Resina, Elena MD2;Muñoz, Raquel MD2;Cano-Català, Anna PhD26;Puig, Ignasi PhD27;García-Morales, Natalia MD28;Hernández, Luis MD29;Moreira, Leticia PhD30;Megraud, Francis PhD31;Morain, Colm O. PhD32;Montes, Milagrosa Pharm PhD33;Gisbert, Javier P. PhD2;Collaborators Fiorinni, Giulia;Saracino, Ilaria Maria;Pabon Carrasco, Manuel;Keco Huerga, Alma;Alfaro Almajano, Enrique;Martinez Dominguez, Samuel Jesus;Alonso Galan, Horacio;Velayos, Benito;Dueñas Sadornil, Carmen;Botargues Bote, Jose Maria;Gonzalez-Cordero, Pedro Luis;Areia, Miguel;Gomez Rodriguez, Blas Jose;Pellicano, Rinaldo;Nuñez, Óscar;Franceschi, Francesco;Alekseenko, Sergey;Perona, Monica;Abdulkhakov, Rustam;Dominguez-Cajal, Manuel;Almela Notari, Pedro;Gomez Camarero, Judith;Jimenez Moreno, Manuel;Algaba, Alicia;Bermejo, Fernando;Tejedor Tejada, Javier;Oblitas Susanibar, Elida;Boltin, Doron;Georgopoulos, Sotirios;OMorain, Colm;Qasim, Asghar;Beales, Ian;Bakulina, Natalia;Fadeenko, Galina;Malfertheiner, Peter;Rosania, Rosa;Ilchishina, Tatiana;Bogomolov, Pavel;Bakulin, Igor;Zaytsev, Oleg;Gravina, Antonietta Gerarda;Romano, Marco;Di Leo, Alfredo;Losurdo, Giuseppe;Grigorieva, Ludmila;Delgado Guillena, Pedro;Marusic, Marinko;Jurcic, Dragan;Dekhnich, Natalia Nikolaevna;Iyo, Eduardo;de la Peña Negro, Luisa Carmen;Baryshnikova, Natalia;Bakanova, Natalia;Simsek, Halis;Simsek, Cem;Gridnyev, Oleksiy;Fernandez-Bermejo, Miguel;Angueira, Teresa;Ruiz-Zorrilla Lopez, Rafael;Gomez, Barbara;Kovacheva-Slavova, Mila;Lahat, Adi;Alcedo, Javier;Campillo, Ana;Nikolaevna Belousova, Liya;Pajares Villarroya, Ramon;Ljubicic, Neven;Nikolic, Marko;González-Santiago, Jesús M;Santamaría, Diego Burgos;Pakhomova, Anna;Sekulic-Spasic, Izabela;Ghisa, Matteo;Farinati, Fabio;Sagdati, Sabir Irfan;Panic, Nikola;Heluwaert, Frederic;Amorena, Edurne;Moreira, Leticia;Fernandez Esparrach, Gloria;Yuryevna Plotnikova, Ekaterina;Kukla, Michal;Kamburov, Victor;Lamuela Calvo, Luis Javier;Rankovic, Ivan;Cuadrado Lavín, Antonio;Arguedas Lazaro, Yolanda;Gonzalez Carrera, Victor;Dobrowolska, Agnieszka;Eder, Piotr;Kononova, AllWojciech;Venerito, Marino;Vologzanina, Ludmila;Fadieienko, Galina D;Fiorini, Giulia;Resina, Elena;Muñoz, Raquel;Cano-Català, Anna;Puig, Ignasi;García-Morales, Natalia;Hernández, Luis;Moreira, Leticia;Megraud, Francis;Morain, Colm O;Montes, Milagrosa;Gisbert, Javier P
2024
Abstract
INTRODUCTION:Antibiotic resistance is one of the main factors that determine the efficacy of treatments to eradicate Helicobacter pylori infection. Our aim was to evaluate the effectiveness of first-line and rescue treatments against H. pylori in Europe according to antibiotics resistance. METHODS:Prospective, multicenter, international registry on the management of H. pylori (European Registry on H. pylori Management). All infected and culture-diagnosed adult patients registered in the Spanish Association of Gastroenterology-Research Electronic Data Capture from 2013 to 2021 were included. RESULTS:A total of 2,852 naive patients with culture results were analyzed. Resistance to clarithromycin, metronidazole, and quinolones was 22%, 27%, and 18%, respectively. The most effective treatment, regardless of resistance, were the 3-in-1 single capsule with bismuth, metronidazole, and tetracycline (91%) and the quadruple with bismuth, offering optimal cure rates even in the presence of bacterial resistance to clarithromycin or metronidazole. The concomitant regimen with tinidazole achieved an eradication rate of 99% (90/91) vs 84% (90/107) with metronidazole. Triple schedules, sequential, or concomitant regimen with metronidazole did not achieve optimal results. A total of 1,118 non-naive patients were analyzed. Resistance to clarithromycin, metronidazole, and quinolones was 49%, 41%, and 24%, respectively. The 3-in-1 single capsule (87%) and the triple therapy with levofloxacin (85%) were the only ones that provided encouraging results. DISCUSSION:In regions where the antibiotic resistance rate of H. pylori is high, eradication treatment with the 3-in-1 single capsule, the quadruple with bismuth, and concomitant with tinidazole are the best options in naive patients. In non-naive patients, the 3-in-1 single capsule and the triple therapy with levofloxacin provided encouraging results.
Bujanda, L., Nyssen, O. P., Ramos, J., Bordin, D. S., Tepes, B., Perez-Aisa, A., Pavoni, M., Castro-Fernandez, M., Lerang, F., Leja, M., Rodrigo, L., Rokkas, T., Kupcinskas, J., Jonaitis, L., Shvets, O., Gasbarrini, A., Simsek, H., Phull, P. S., Buzás, G. M., Machado, J. C., Boltin, D., Boyanova, L., Tonkić, A., Marlicz,, Article: Stomach Effectiveness Of Helicobacter Pylori Treatments According To Antibiotic Resistance, B., Luis, M., Phd1,, Nyssen, O. P. P., Ramos, J. M., Bordin, D. S. M., Tepes, B. M., Perez-Aisa, A. P., Pavoni, M. M., Castro-Fernandez, M. P., Lerang, F. M., Leja, M. M., Rodrigo, L. P., Rokkas, T. P., Kupcinskas, J. M., Jonaitis, L. M., Shvets, O. M., Gasbarrini, A. P., Simsek, H. M., Phull, P. S. M., Buzás, G. M. M., Machado, J. C. M., Boltin, D. M., Boyanova, L. M., Tonkić, A. M., Marlicz, W. M., Venerito, M. M., Vologzanina, L. M., Fadieienko, G. D. M., Fiorini, G. M., Resina, E. M., Muñoz, R. M., Cano-Català, A. P., Puig, I. P., García-Morales, N. M., Hernández, L. M., Moreira, L. P., Megraud, F. P., Morain, C. O. P., Montes, M. P. P., Gisbert, J. P. P., Collaborators Fiorinni, G., Saracino, I. M., Pabon Carrasco, M., Keco Huerga, A., Alfaro Almajano, E., Martinez Dominguez, S. J., Alonso Galan, H., Velayos, B., Dueñas Sadornil, C., Botargues Bote, J. M., Gonzalez-Cordero, P. L., Areia, M., Gomez Rodriguez, B. J., Pellicano, R., Nuñez, Ó., Franceschi, F., Alekseenko, S., Perona, M., Abdulkhakov, R., Dominguez-Cajal, M., Almela Notari, P., Gomez Camarero, J., Jimenez Moreno, M., Algaba, A., Bermejo, F., Tejedor Tejada, J., Oblitas Susanibar, E., Boltin, D., Georgopoulos, S., Omorain, C., Qasim, A., Beales, I., Bakulina, N., Fadeenko, G., Malfertheiner, P., Rosania, R., Ilchishina, T., Bogomolov, P., Bakulin, I., Zaytsev, O., Gravina, A. G., Romano, M., Di Leo, A., Losurdo, G., Grigorieva, L., Delgado Guillena, P., Marusic, M., Jurcic, D., Dekhnich, N. N., Iyo, E., De La Peña Negro, L. C., Baryshnikova, N., Bakanova, N., Simsek, H., Simsek, C., Gridnyev, O., Fernandez-Bermejo, M., Angueira, T., Ruiz-Zorrilla Lopez, R., Gomez, B., Kovacheva-Slavova, M., Lahat, A., Alcedo, J., Campillo, A., Nikolaevna Belousova, L., Pajares Villarroya, R., Ljubicic, N., Nikolic, M., González-Santiago, J. M., Santamaría, D. B., Pakhomova, A., Sekulic-Spasic, I., Ghisa, M., Farinati, F., Sagdati, S. I., Panic, N., Heluwaert, F., Amorena, E., Moreira, L., Fernandez Esparrach, G., Yuryevna Plotnikova, E., Kukla, M., Kamburov, V., Lamuela Calvo, L. J., Rankovic, I., Cuadrado Lavín, A., Arguedas Lazaro, Y., Gonzalez Carrera, V., Dobrowolska, A., Eder, P., Kononova, A., Venerito, M., Vologzanina, L., Fadieienko, G. D., Fiorini, G., Resina, E., Muñoz, R., Cano-Català, A., Puig, I., García-Morales, N., Hernández, L., Moreira, L., Megraud, F., Morain, C. O., Montes, M., Gisbert, J. P., Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance, <<THE AMERICAN JOURNAL OF GASTROENTEROLOGY>>, N/A; 119 (4): N/A-N/A. [doi:10.14309/ajg.0000000000002600] [https://hdl.handle.net/10807/292158]
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.