Reelin-deficient mice have been used to investigate the role of this extracellular protein in cortico-striatal plasticity and striatum-related behaviours. Here we show that a repetitive electrical stimulation of the cortico-striatal pathway elicited long-term potentiation (LTP) in homozygous reeler (rl/rl) mice, while causing long-term depression in their wild-type (+/+) littermates. The N-methyl-d-aspartic acid (NMDA) receptor antagonist d-(–)-2 amino-5-phosphonopentanoic acid prevented the induction of LTP in (rl/rl) mice, thus confirming that this form of synaptic plasticity was NMDA receptor-dependent. Interestingly, in the presence of tiagabine, a blocker of γ-aminobutyric acid (GABA) re-uptake system, the probability that (rl/rl) mice showed LTP decreased significantly, thus suggesting an impaired GABAergic transmission in reeler mutants. Consistent with this view, a decreased density of parvalbumin-positive GABAergic striatal interneurons was found in (rl/rl) mice in comparison to (+/+) mice. Finally, compatible with their abnormal striatal function (rl/rl) mice exhibited procedural learning deficits. Our data, showing alterations in cortico-striatal plasticity largely depending on a depressed GABAergic tone, delineate a mechanism whereby the lack of reelin may affect cognitive functions.

Marrone, M. C., Marinelli, S., Biamonte, F., Keller, F., Carmelo Alessio, S., Ammassari Teule, M., Bernardi, G., Mercuri, B. N., Altered cortico-striatal plasticity and related behavioural parameters in reeler mice. European Journal of Neuroscience, Vol. 24, pp. 2061–2070, 2006, <<EUROPEAN JOURNAL OF NEUROSCIENCE>>, 2006; 24 (Ottobre): 2061-2070 [http://hdl.handle.net/10807/28770]

Altered cortico-striatal plasticity and related behavioural parameters in reeler mice. European Journal of Neuroscience, Vol. 24, pp. 2061–2070, 2006

Biamonte, Filippo;
2006

Abstract

Reelin-deficient mice have been used to investigate the role of this extracellular protein in cortico-striatal plasticity and striatum-related behaviours. Here we show that a repetitive electrical stimulation of the cortico-striatal pathway elicited long-term potentiation (LTP) in homozygous reeler (rl/rl) mice, while causing long-term depression in their wild-type (+/+) littermates. The N-methyl-d-aspartic acid (NMDA) receptor antagonist d-(–)-2 amino-5-phosphonopentanoic acid prevented the induction of LTP in (rl/rl) mice, thus confirming that this form of synaptic plasticity was NMDA receptor-dependent. Interestingly, in the presence of tiagabine, a blocker of γ-aminobutyric acid (GABA) re-uptake system, the probability that (rl/rl) mice showed LTP decreased significantly, thus suggesting an impaired GABAergic transmission in reeler mutants. Consistent with this view, a decreased density of parvalbumin-positive GABAergic striatal interneurons was found in (rl/rl) mice in comparison to (+/+) mice. Finally, compatible with their abnormal striatal function (rl/rl) mice exhibited procedural learning deficits. Our data, showing alterations in cortico-striatal plasticity largely depending on a depressed GABAergic tone, delineate a mechanism whereby the lack of reelin may affect cognitive functions.
eng
Marrone, M. C., Marinelli, S., Biamonte, F., Keller, F., Carmelo Alessio, S., Ammassari Teule, M., Bernardi, G., Mercuri, B. N., Altered cortico-striatal plasticity and related behavioural parameters in reeler mice. European Journal of Neuroscience, Vol. 24, pp. 2061–2070, 2006, <>, 2006; 24 (Ottobre): 2061-2070 [http://hdl.handle.net/10807/28770]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/28770
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