Background: A correlation between plasma lipids and timing of pubertal development has been hypothesized, though lipid influence remains unclear in central precocious puberty (CPP). Aim: To assess any possible alterations in the lipid profile and triglyceride glucose index (TyG) in children diagnosed with CPP. Patients and Methods: Retrospective single-center study conducted on children (aged 6.3 ± 2.1 years) evaluated for the suspicion of CPP. Results: Based on the results of the gonadotropin releasing hormone (GnRH) test, considering 5 IU/L as cut-off of for the luteinizing hormone peak, CPP was confirmed in 43 patients (57.3%). Sixteen (37.2%) had a pathologic body mass index (BMI), with 9 (20.9%) being overweight and 7 (16.27%) obese. High total cholesterol was found in 3 patients with CPP (6.97%), high triglycerides were found in 11 patients with CPP (25.58%), high LDL cholesterol was found in 5 patients with CPP (11.62%), low HDL cholesterol was found in 12/43 patients with CPP (27.9%), a pathologic TyG was found in 13/43 patients with CPP (30.23%). No significant association was observed in the lipid profile for patients with or without CPP, except for HDL cholesterol, which was lower in the CPP group (47.1±10.9; p=0.033). However, the association between serum HDL cholesterol and CPP was not confirmed at the multivariate logistic regression analysis adjusted for patients’ sex and age (p=0.1; OR: 1.035; 95%CI: 0.993-1.078). Conclusion: The overall lipid profile of our pediatric patients diagnosed with CPP did not differ from patients having idiopathic precocious thelarche or normal variants of puberty development.

Sodero, G., Pane, L. C., Malavolta, E., Rotunno, G., Sessa, L., Fraccascia, B., Candelli, M., Rigante, D., Cipolla, C., Lipid profile and triglyceride-glucose index (TyG) alterations in a single-center cohort of children diagnosed with central precocious puberty, <<CHILDREN>>, 2024; 2024 (11(6): 639): 1-10. [doi:10.3390/children11060639] [https://hdl.handle.net/10807/281758]

Lipid profile and triglyceride-glucose index (TyG) alterations in a single-center cohort of children diagnosed with central precocious puberty

Sodero, Giorgio
;
Pane, Lucia Celeste;Malavolta, Elena;Rotunno, Giulia;Sessa, Linda;Fraccascia, Barbara;Candelli, Marcello;Rigante, Donato;Cipolla, Clelia
2024

Abstract

Background: A correlation between plasma lipids and timing of pubertal development has been hypothesized, though lipid influence remains unclear in central precocious puberty (CPP). Aim: To assess any possible alterations in the lipid profile and triglyceride glucose index (TyG) in children diagnosed with CPP. Patients and Methods: Retrospective single-center study conducted on children (aged 6.3 ± 2.1 years) evaluated for the suspicion of CPP. Results: Based on the results of the gonadotropin releasing hormone (GnRH) test, considering 5 IU/L as cut-off of for the luteinizing hormone peak, CPP was confirmed in 43 patients (57.3%). Sixteen (37.2%) had a pathologic body mass index (BMI), with 9 (20.9%) being overweight and 7 (16.27%) obese. High total cholesterol was found in 3 patients with CPP (6.97%), high triglycerides were found in 11 patients with CPP (25.58%), high LDL cholesterol was found in 5 patients with CPP (11.62%), low HDL cholesterol was found in 12/43 patients with CPP (27.9%), a pathologic TyG was found in 13/43 patients with CPP (30.23%). No significant association was observed in the lipid profile for patients with or without CPP, except for HDL cholesterol, which was lower in the CPP group (47.1±10.9; p=0.033). However, the association between serum HDL cholesterol and CPP was not confirmed at the multivariate logistic regression analysis adjusted for patients’ sex and age (p=0.1; OR: 1.035; 95%CI: 0.993-1.078). Conclusion: The overall lipid profile of our pediatric patients diagnosed with CPP did not differ from patients having idiopathic precocious thelarche or normal variants of puberty development.
2024
Inglese
Sodero, G., Pane, L. C., Malavolta, E., Rotunno, G., Sessa, L., Fraccascia, B., Candelli, M., Rigante, D., Cipolla, C., Lipid profile and triglyceride-glucose index (TyG) alterations in a single-center cohort of children diagnosed with central precocious puberty, <<CHILDREN>>, 2024; 2024 (11(6): 639): 1-10. [doi:10.3390/children11060639] [https://hdl.handle.net/10807/281758]
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