To the Editor: Del Bufalo et al. (April 6 issue)(1) describe the treatment of patients with relapsed or refractory pediatric neuroblastoma with chimeric antigen receptor (CAR)-expressing T cells that target the disialoganglioside GD2 and express the inducible capsase 9 suicide gene (GD2-CART01). Among the children who had a relapse after this treatment, the authors did not observe reexpansion of T cells, and the GD2 antigen was still expressed on tumor cells. We were surprised by the surface-marker analysis of the GD2-CAR T cells that led the authors to conclude that these cells were not exhausted. The data show that the . . .

Quintarelli, C., Del Bufalo, F., Locatelli, F., GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma. Reply, <<THE NEW ENGLAND JOURNAL OF MEDICINE>>, 2023; 388 (24): 2303-2304. [doi:10.1056/NEJMc2305296] [https://hdl.handle.net/10807/276680]

GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma. Reply

Locatelli, Franco
Ultimo
Supervision
2023

Abstract

To the Editor: Del Bufalo et al. (April 6 issue)(1) describe the treatment of patients with relapsed or refractory pediatric neuroblastoma with chimeric antigen receptor (CAR)-expressing T cells that target the disialoganglioside GD2 and express the inducible capsase 9 suicide gene (GD2-CART01). Among the children who had a relapse after this treatment, the authors did not observe reexpansion of T cells, and the GD2 antigen was still expressed on tumor cells. We were surprised by the surface-marker analysis of the GD2-CAR T cells that led the authors to conclude that these cells were not exhausted. The data show that the . . .
2023
Inglese
Quintarelli, C., Del Bufalo, F., Locatelli, F., GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma. Reply, <<THE NEW ENGLAND JOURNAL OF MEDICINE>>, 2023; 388 (24): 2303-2304. [doi:10.1056/NEJMc2305296] [https://hdl.handle.net/10807/276680]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/276680
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