: Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.
Teofili, L., Papacci, P., Giannantonio, C., Bianchi, M., Giovanna Valentini, C., Vento, G., Allogenic Cord Blood Transfusion in Preterm Infants, <<CLINICS IN PERINATOLOGY>>, 2023; 50 (4): 881-893. [doi:10.1016/j.clp.2023.07.005] [https://hdl.handle.net/10807/274458]
Allogenic Cord Blood Transfusion in Preterm Infants
Teofili, Luciana
;Papacci, Patrizia;Giannantonio, Carmen;Vento, Giovanni
2023
Abstract
: Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.
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