This is an observational case–control study performed at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS, including subjects with a molecular diagnosis of primary mitochondrial myopathy. Full demographic and clinical data of the MD patients and healthy controls (HCs) are reported in Data S1. Thirty adult patients with a genetically defined MD with predominant involvement of skeletal muscle and 26 age-and sex-matched HCs were included in the studySumming up, our results suggest that inflammation plays a role in primary MDs and may represent an interesting field for future therapeutic perspectives.
Primiano, G. A., Plantone, D., Piro, G., Carbone, C., Sabino, A., Sancricca, C., Di Nottia, M., Carrozzo, R., Servidei, S., Inflammatory profile in mitochondrial diseases: A cohort study, <<EUROPEAN JOURNAL OF NEUROLOGY>>, 2023; 30 (10): 3409-3410. [doi:10.1111/ene.15962] [https://hdl.handle.net/10807/274080]
Inflammatory profile in mitochondrial diseases: A cohort study
Primiano, Guido AlessandroPrimo
;Carbone, Carmine;Sancricca, Cristina;Servidei, SerenellaUltimo
2023
Abstract
This is an observational case–control study performed at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS, including subjects with a molecular diagnosis of primary mitochondrial myopathy. Full demographic and clinical data of the MD patients and healthy controls (HCs) are reported in Data S1. Thirty adult patients with a genetically defined MD with predominant involvement of skeletal muscle and 26 age-and sex-matched HCs were included in the studySumming up, our results suggest that inflammation plays a role in primary MDs and may represent an interesting field for future therapeutic perspectives.
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