Vaccinations are among the most effective medical procedures and have had an incredible impact on almost everyone’s life. One of the populations that can benefit the most from them are elderly people. Unfortunately, in this group, vaccines are less effective than in other groups, due to immunosenescence. The immune system ages like the whole body and becomes less effective in responding to infections and vaccinations. At the same time, immunosenescence also favors an inflammatory microenvironment, which is linked to many conditions typical of the geriatrics population. The microbiota is one of the key actors in modulating the immune response and, in this review, we discuss the current evidence on the role of microbiota in regulating the immune response to vaccines, particularly in elderly people.

Cianci, R., Franza, L., Massaro, M. G., Borriello, R., De Vito, F., Gambassi, G., The interplay between immunosenescence and microbiota in the efficacy of vaccines, <<VACCINES>>, 2020; 8 (4): 1-16. [doi:10.3390/vaccines8040636] [https://hdl.handle.net/10807/270525]

The interplay between immunosenescence and microbiota in the efficacy of vaccines

Cianci, Rossella
Primo
;
Franza, Laura
Secondo
;
Massaro, Maria Grazia;Borriello, Raffaele;De Vito, Francesco
Penultimo
;
Gambassi, Giovanni
Ultimo
2020

Abstract

Vaccinations are among the most effective medical procedures and have had an incredible impact on almost everyone’s life. One of the populations that can benefit the most from them are elderly people. Unfortunately, in this group, vaccines are less effective than in other groups, due to immunosenescence. The immune system ages like the whole body and becomes less effective in responding to infections and vaccinations. At the same time, immunosenescence also favors an inflammatory microenvironment, which is linked to many conditions typical of the geriatrics population. The microbiota is one of the key actors in modulating the immune response and, in this review, we discuss the current evidence on the role of microbiota in regulating the immune response to vaccines, particularly in elderly people.
2020
Inglese
Cianci, R., Franza, L., Massaro, M. G., Borriello, R., De Vito, F., Gambassi, G., The interplay between immunosenescence and microbiota in the efficacy of vaccines, <<VACCINES>>, 2020; 8 (4): 1-16. [doi:10.3390/vaccines8040636] [https://hdl.handle.net/10807/270525]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/270525
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