Experimental results and computational insights explain the key role of transition-metal catalysis/Bronsted acid synergism in the achievement of the sequential regioselective direct heteroarylation/ cyclocondensation reactions of beta-(2-aminophenyl)-alpha,beta-ynones with a variety of electron-rich aromatic heterocyclic/arenes to afford quinoline-(hetero)aromatic hybrids. The first approach to the synthesis of 4-(1H-pyrrol-2-yl)quinolines is described. The effectiveness of various transition metals is compared.

Marsicano, V., Arcadi, A., Aschi, M., Chiarini, M., Fabrizi, G., Goggiamani, A., Marinelli, F., Iazzetti, A., Direct Regioselective Hydro(hetero)arylation/Cyclocondensation Reactions of β-(2-Aminophenyl)-α,β-ynones by Means of Transition-Metal Catalysis/Brønsted Acid Synergism: Experimental Results and Computational Insights, <<JOURNAL OF ORGANIC CHEMISTRY>>, 2023; 88 (11): 6857-6867. [doi:10.1021/acs.joc.3c00137] [https://hdl.handle.net/10807/270315]

Direct Regioselective Hydro(hetero)arylation/Cyclocondensation Reactions of β-(2-Aminophenyl)-α,β-ynones by Means of Transition-Metal Catalysis/Brønsted Acid Synergism: Experimental Results and Computational Insights

Goggiamani, Antonella;Iazzetti, Antonia
2023

Abstract

Experimental results and computational insights explain the key role of transition-metal catalysis/Bronsted acid synergism in the achievement of the sequential regioselective direct heteroarylation/ cyclocondensation reactions of beta-(2-aminophenyl)-alpha,beta-ynones with a variety of electron-rich aromatic heterocyclic/arenes to afford quinoline-(hetero)aromatic hybrids. The first approach to the synthesis of 4-(1H-pyrrol-2-yl)quinolines is described. The effectiveness of various transition metals is compared.
2023
Inglese
Marsicano, V., Arcadi, A., Aschi, M., Chiarini, M., Fabrizi, G., Goggiamani, A., Marinelli, F., Iazzetti, A., Direct Regioselective Hydro(hetero)arylation/Cyclocondensation Reactions of β-(2-Aminophenyl)-α,β-ynones by Means of Transition-Metal Catalysis/Brønsted Acid Synergism: Experimental Results and Computational Insights, <<JOURNAL OF ORGANIC CHEMISTRY>>, 2023; 88 (11): 6857-6867. [doi:10.1021/acs.joc.3c00137] [https://hdl.handle.net/10807/270315]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/270315
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