: We report the case of a 4-year-old female with high-risk ALL in first CR who received a BMT from an 11-month-old matched sibling treated with G-CSF in order to obtain an adequate number of mononuclear cells in a limited volume of bone marrow. The absence of toxicity, efficacy of the procedure and quality of the post-transplant clinical outcome suggest such treatments are feasible and useful to overcome problems caused by donor age and/or body weight. In view of this experience we demonstrate how such an approach leads to a notable reduction in risks and in bone marrow donation costs.
Pession, A., Locatelli, F., Prete, A., Pigna, A., Magrini, E., Conte, R., Rosito, P., Paolucci, G., G-CSF in an infant donor: a method of reducing harvest volume in bone marrow transplantation, <<BONE MARROW TRANSPLANTATION>>, 1996; 17 (3): 431-432 [https://hdl.handle.net/10807/269912]
G-CSF in an infant donor: a method of reducing harvest volume in bone marrow transplantation
Locatelli, Franco;
1996
Abstract
: We report the case of a 4-year-old female with high-risk ALL in first CR who received a BMT from an 11-month-old matched sibling treated with G-CSF in order to obtain an adequate number of mononuclear cells in a limited volume of bone marrow. The absence of toxicity, efficacy of the procedure and quality of the post-transplant clinical outcome suggest such treatments are feasible and useful to overcome problems caused by donor age and/or body weight. In view of this experience we demonstrate how such an approach leads to a notable reduction in risks and in bone marrow donation costs.
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