Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.
Florio, A., Ferrari, S., De Carolis, E., Torelli, R., Fadda, G., Sanguinetti, M., Sanglard, D., Posteraro, B., Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A, <<BMC MICROBIOLOGY>>, 2011; 11 (11): 97-97. [doi:10.1186/1471-2180-11-97] [http://hdl.handle.net/10807/2663]
Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A
De Carolis, Elena;Torelli, Riccardo;Fadda, Giovanni;Sanguinetti, Maurizio;Posteraro, Brunella
2011
Abstract
Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.
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