Combination of endoscopic ultrasound-guided radiofrequency ablation and adaptive radiation therapy for the treatment of lymph node metastases from colon adenocarcinoma: A case report

Oligometastatic colorectal cancer (CRC) is a clinically relevant entity, and surgery is the gold standard therapeutic option. Current guidelines recommend evaluating other local ablative treatments (LATs) in patients not eligible for surgery. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and stereotactic body radiation therapy (SBRT) are emerging as highly beneficial less-invasive LATs in alternative to surgery. In our paper, we report the first case in literature of lymph node metastases from CRC treated sequentially with EUS-RFA and SBRT, providing evidence of their efficacy and safety. LATs combined with systemic chemotherapy might be included in a multimodal therapeutic approach to oligometastatic disease.