: Since children with myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD) have a poor prognosis and conventional chemotherapy did not prove to be effective in eradicating them, paediatric patients affected by these diseases and with an HLA-histocompatible donor are to be considered elective candidates for allogeneic transplantation of haematopoietic stem cells (HSC). For those patients with a compatible sibling relapse remains the most important problem, whereas in children transplanted from alternative donors graft rejection and transplant-related mortality significantly contribute to treatment failure. A detailed analysis on the different patient, disease and treatment factors correlated with transplant outcome in childhood MDS and MPD is discussed.

Locatelli, F., Giorgiani, G., Comoli, P., Allogeneic transplantation of haematopoietic progenitors for myelodysplastic syndromes and myeloproliferative disorders, <<BONE MARROW TRANSPLANTATION>>, 1998; 21 (suppl 2): 17-20 [https://hdl.handle.net/10807/264695]

Allogeneic transplantation of haematopoietic progenitors for myelodysplastic syndromes and myeloproliferative disorders

Locatelli, Franco;
1998

Abstract

: Since children with myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD) have a poor prognosis and conventional chemotherapy did not prove to be effective in eradicating them, paediatric patients affected by these diseases and with an HLA-histocompatible donor are to be considered elective candidates for allogeneic transplantation of haematopoietic stem cells (HSC). For those patients with a compatible sibling relapse remains the most important problem, whereas in children transplanted from alternative donors graft rejection and transplant-related mortality significantly contribute to treatment failure. A detailed analysis on the different patient, disease and treatment factors correlated with transplant outcome in childhood MDS and MPD is discussed.
1998
Inglese
Locatelli, F., Giorgiani, G., Comoli, P., Allogeneic transplantation of haematopoietic progenitors for myelodysplastic syndromes and myeloproliferative disorders, <<BONE MARROW TRANSPLANTATION>>, 1998; 21 (suppl 2): 17-20 [https://hdl.handle.net/10807/264695]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/264695
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