Natural killer (NK) cells express surface receptors that regulate potent effector functions, such as cytolytic activity and release of cytokines, which play a central role in inflammatory response and immunoregulation. In this paper, major advances are outlined from the original discovery of HLA-class I-specific inhibitory receptors in humans to recent, particularly successful, clinical applications in the cure of high-risk, otherwise fatal leukaemias. The central role of donor-derived "alloreactive'' NK cells in eradicating leukaemic cells in the T-cell-depleted haploidentical haematopoietic stem cell transplantation setting became evident. Since alloreactive NK cells seem to play a key role also in preventing graft rejection and graft-vs-host disease, they may be an ideal tool to treat high-risk leukaemias in the haematopoietic stem cell transplantation setting.

Moretta, L., Locatelli, F., Moretta, A., Alloreactive natural killer cells in targeting high-risk leukaemias, <<EARD>>, 2009; 67 Suppl 3 (SUPPL. 3): 39-43. [doi:10.1136/ard.2008.097980] [https://hdl.handle.net/10807/258294]

Alloreactive natural killer cells in targeting high-risk leukaemias

Locatelli, Franco;
2008

Abstract

Natural killer (NK) cells express surface receptors that regulate potent effector functions, such as cytolytic activity and release of cytokines, which play a central role in inflammatory response and immunoregulation. In this paper, major advances are outlined from the original discovery of HLA-class I-specific inhibitory receptors in humans to recent, particularly successful, clinical applications in the cure of high-risk, otherwise fatal leukaemias. The central role of donor-derived "alloreactive'' NK cells in eradicating leukaemic cells in the T-cell-depleted haploidentical haematopoietic stem cell transplantation setting became evident. Since alloreactive NK cells seem to play a key role also in preventing graft rejection and graft-vs-host disease, they may be an ideal tool to treat high-risk leukaemias in the haematopoietic stem cell transplantation setting.
2008
Inglese
Moretta, L., Locatelli, F., Moretta, A., Alloreactive natural killer cells in targeting high-risk leukaemias, <<EARD>>, 2009; 67 Suppl 3 (SUPPL. 3): 39-43. [doi:10.1136/ard.2008.097980] [https://hdl.handle.net/10807/258294]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/258294
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