Currently available NSAIDs represent a heterogeneous group of therapeutic agents characterized by a variable benefit/risk profile. The development of a new class of selective COX-2 inhibitors, the coxibs, has contributed importantly to clarifying the discrete roles of COX-2 vs. COX-1 inhibition in different aspects of NSAID-related efficacy and safety. Cardiovascular toxicity has emerged as a previously unrecognized, mechanism-based effect of COX-2 inhibitors. Lessons learned from the many facets of the coxib failure story may help guiding the successful development of a new class of safer NSAIDs, targeting mediators unrelated to arachidonic acid metabolism or molecular targets downstream of COX-isozymes.

Patrono, C., Rocca, B., Nonsteroidal antiinflammatory drugs: past, present and future, <<Pharmacological research : the official journal of the Italian Pharmacological Society>>, 2009; 59 (5): 285-289. [doi:10.1016/j.phrs.2009.01.011] [http://hdl.handle.net/10807/25333]

Nonsteroidal antiinflammatory drugs: past, present and future

Patrono, Carlo;Rocca, Bianca
2009

Abstract

Currently available NSAIDs represent a heterogeneous group of therapeutic agents characterized by a variable benefit/risk profile. The development of a new class of selective COX-2 inhibitors, the coxibs, has contributed importantly to clarifying the discrete roles of COX-2 vs. COX-1 inhibition in different aspects of NSAID-related efficacy and safety. Cardiovascular toxicity has emerged as a previously unrecognized, mechanism-based effect of COX-2 inhibitors. Lessons learned from the many facets of the coxib failure story may help guiding the successful development of a new class of safer NSAIDs, targeting mediators unrelated to arachidonic acid metabolism or molecular targets downstream of COX-isozymes.
2009
Inglese
Patrono, C., Rocca, B., Nonsteroidal antiinflammatory drugs: past, present and future, <<Pharmacological research : the official journal of the Italian Pharmacological Society>>, 2009; 59 (5): 285-289. [doi:10.1016/j.phrs.2009.01.011] [http://hdl.handle.net/10807/25333]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/25333
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