A morphometric study of the striatal complex has been performed in adult and aged rats, by means of Butcher's acetylcholinesterase (AChE) staining. The size of neostriatum, and the number of putatively cholinergic AChE-positive perikarya, are significantly reduced in two-year-old rats. Consequently, mean cell density is decreased in the striatal complex by 15.58%; age-dependent loss is more pronounced: (1) in the dorsal and lateral parts of neostriatum, which in adults have a higher neural density; and (2) in the ventromedial part, which in the aged becomes almost void of neurones. It is concluded that depletion of cholinergic perikarya is a specific feature of natural ageing, which affects diffusely the neostriatum, and particularly its ventromedial territories.

Altavista, M., Bentivoglio, A. R., Crociani, P., Rossi, P., Albanese, A., Age-dependent loss of cholinergic neurones in basal ganglia of rats, <<BRAIN RESEARCH>>, 1988; 455 (1): 177-181. [doi:10.1016/0006-8993(88)90130-8] [http://hdl.handle.net/10807/25186]

Age-dependent loss of cholinergic neurones in basal ganglia of rats

Bentivoglio, Anna Rita;Albanese, Alberto
1988

Abstract

A morphometric study of the striatal complex has been performed in adult and aged rats, by means of Butcher's acetylcholinesterase (AChE) staining. The size of neostriatum, and the number of putatively cholinergic AChE-positive perikarya, are significantly reduced in two-year-old rats. Consequently, mean cell density is decreased in the striatal complex by 15.58%; age-dependent loss is more pronounced: (1) in the dorsal and lateral parts of neostriatum, which in adults have a higher neural density; and (2) in the ventromedial part, which in the aged becomes almost void of neurones. It is concluded that depletion of cholinergic perikarya is a specific feature of natural ageing, which affects diffusely the neostriatum, and particularly its ventromedial territories.
1988
Inglese
Altavista, M., Bentivoglio, A. R., Crociani, P., Rossi, P., Albanese, A., Age-dependent loss of cholinergic neurones in basal ganglia of rats, <<BRAIN RESEARCH>>, 1988; 455 (1): 177-181. [doi:10.1016/0006-8993(88)90130-8] [http://hdl.handle.net/10807/25186]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/25186
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