Background: Small bowel cleansing by capsule endoscopy has never been addressed in children. Methods: Randomized controlled trial to evaluate the effect of five bowel preparation regimens on the mucosal visibility surface (as percentage of visualized surface area). Group A: a clear liquid diet for 12. h on the day before; Group B: high volume polyethylene glycol (50. mL/kg, up to 2. Lt/die); Group C: low volume polyethylene glycol (25. mL/kg up to 1. Lt/die); Group D: 20. mL (376. mg) of oral simethicone; Group E: 25. mL/kg (up to 1. Lt/die) of polyethylene glycol solution plus 20. mL (376. mg) of oral simethicone. Results: Overall, 198 patients (53% male, median age 13 years) were enrolled. Preparation regimen visualization scores were 14.1. ±. 4.2, 18.9. ±. 5.1, 17.8. ±. 5.5, 14.9. ±. 4.8 and 20.9. ±. 4.6 in groups A, B, C, D and E, respectively (P<. 0.01). Positive findings were found in 172 cases (87%), but no significant differences were observed in the diagnostic yield and tolerability. Interobserver agreement, k=0.89 (95% CI 0.83. ±. 0.71). Conclusion: This is the first report in children that supports the use of 25. mL/kg (up to 1. Lt/die) of polyethylene glycol solution plus 20. mL (376. mg) of oral simethicone as the preparation of choice for capsule endoscopy. © 2013 Editrice Gastroenterologica Italiana S.r.l.
Oliva, S. C., Cucchiara, S., Spada, C., Hassan, C., Ferrari, F., Civitelli, F., Pagliaro, G., Di Nardo, G., Small bowel cleansing for capsule endoscopy in paediatric patients: A prospective randomized single-blind study, <<DIGESTIVE AND LIVER DISEASE>>, 2014; 46 (1): 51-55. [doi:10.1016/j.dld.2013.08.130] [https://hdl.handle.net/10807/251039]
Small bowel cleansing for capsule endoscopy in paediatric patients: A prospective randomized single-blind study
Oliva, Stefano Claudio;Spada, Cristiano;Hassan, Cesare;
2014
Abstract
Background: Small bowel cleansing by capsule endoscopy has never been addressed in children. Methods: Randomized controlled trial to evaluate the effect of five bowel preparation regimens on the mucosal visibility surface (as percentage of visualized surface area). Group A: a clear liquid diet for 12. h on the day before; Group B: high volume polyethylene glycol (50. mL/kg, up to 2. Lt/die); Group C: low volume polyethylene glycol (25. mL/kg up to 1. Lt/die); Group D: 20. mL (376. mg) of oral simethicone; Group E: 25. mL/kg (up to 1. Lt/die) of polyethylene glycol solution plus 20. mL (376. mg) of oral simethicone. Results: Overall, 198 patients (53% male, median age 13 years) were enrolled. Preparation regimen visualization scores were 14.1. ±. 4.2, 18.9. ±. 5.1, 17.8. ±. 5.5, 14.9. ±. 4.8 and 20.9. ±. 4.6 in groups A, B, C, D and E, respectively (P<. 0.01). Positive findings were found in 172 cases (87%), but no significant differences were observed in the diagnostic yield and tolerability. Interobserver agreement, k=0.89 (95% CI 0.83. ±. 0.71). Conclusion: This is the first report in children that supports the use of 25. mL/kg (up to 1. Lt/die) of polyethylene glycol solution plus 20. mL (376. mg) of oral simethicone as the preparation of choice for capsule endoscopy. © 2013 Editrice Gastroenterologica Italiana S.r.l.
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