Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
De Carolis, M. P., Polimeni, V., Papacci, P., Lacerenza, S., Romagnoli, C., Severe sepsis in a premature neonate: protein C replacement therapy, <<TURKISH JOURNAL OF PEDIATRICS>>, 2008; (Agosto): 405-408 [http://hdl.handle.net/10807/25010]
Severe sepsis in a premature neonate: protein C replacement therapy
De Carolis, Maria Pia;Polimeni, Valentina;Papacci, Patrizia;Lacerenza, Serafina;Romagnoli, Costantino
2008
Abstract
Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
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