Background. Acute B-cell leukemia (B-ALL) is a rare form of pediatric leukemia characterized by a very high-proliferation index, rapid clinical progression, and a high frequency of central nervous system (CNS) involvement. Commonly, it is treated in the clinical trials for Burkitt lymphoma, of which it represents the leukemic counterpart. Procedure. Children with B-ALL diagnosed between 1988 and 1999 were enrolled in the AIEOP-8805 protocol. Treatment included six high-dose chemotherapy courses. No prophylactic CNS irradiation was administered. Results. Sixty-five consecutive patients were enrolled in the study. L3 morphology was observed in 57 of 65 patients (88%). Twenty-five children (38%) had tumor mass in addition to massive bone marrow infiltration; 11 children (17%) had CNS disease at diagnosis. Sixty-two patients obtained complete morphological remission of which 13 suffered a relapse, including 3 with initial CNS involvement. Ten-year overall survival and event-free survival were 77% and 75%, respectively. Neither relevant long-term toxicity nor second malignancies were observed. Conclusions. The AIEOP-8805 confirmed that short high-dose chemotherapy is highly effective for the treatment of B-ALL without significant long-term adverse sequelae. Therapy modifications to reduce relapse rate, such as the use of anti-CD20 monoclonal antibody and more effective,CNS treatment, are being tested. Pediatr Blood Cancer. 2011;56:544-550. (C) 2010 Wiley-Liss, Inc.

Pillon, M., Aricò, M., Basso, G., Locatelli, F., Citterio, M., Micalizzi, C., Testi, A. M., Barisone, E., Nardi, M., Lombardi, A., Rondelli, R., Rosolen, A., Long-term results of AIEOP-8805 protocol for acute B-cell lymphoblastic leukemia of childhood, <<PEDIATRIC BLOOD & CANCER>>, 2011; 56 (4): 544-550. [doi:10.1002/pbc.22787] [https://hdl.handle.net/10807/248342]

Long-term results of AIEOP-8805 protocol for acute B-cell lymphoblastic leukemia of childhood

Locatelli, Franco;
2011

Abstract

Background. Acute B-cell leukemia (B-ALL) is a rare form of pediatric leukemia characterized by a very high-proliferation index, rapid clinical progression, and a high frequency of central nervous system (CNS) involvement. Commonly, it is treated in the clinical trials for Burkitt lymphoma, of which it represents the leukemic counterpart. Procedure. Children with B-ALL diagnosed between 1988 and 1999 were enrolled in the AIEOP-8805 protocol. Treatment included six high-dose chemotherapy courses. No prophylactic CNS irradiation was administered. Results. Sixty-five consecutive patients were enrolled in the study. L3 morphology was observed in 57 of 65 patients (88%). Twenty-five children (38%) had tumor mass in addition to massive bone marrow infiltration; 11 children (17%) had CNS disease at diagnosis. Sixty-two patients obtained complete morphological remission of which 13 suffered a relapse, including 3 with initial CNS involvement. Ten-year overall survival and event-free survival were 77% and 75%, respectively. Neither relevant long-term toxicity nor second malignancies were observed. Conclusions. The AIEOP-8805 confirmed that short high-dose chemotherapy is highly effective for the treatment of B-ALL without significant long-term adverse sequelae. Therapy modifications to reduce relapse rate, such as the use of anti-CD20 monoclonal antibody and more effective,CNS treatment, are being tested. Pediatr Blood Cancer. 2011;56:544-550. (C) 2010 Wiley-Liss, Inc.
2011
Inglese
Pillon, M., Aricò, M., Basso, G., Locatelli, F., Citterio, M., Micalizzi, C., Testi, A. M., Barisone, E., Nardi, M., Lombardi, A., Rondelli, R., Rosolen, A., Long-term results of AIEOP-8805 protocol for acute B-cell lymphoblastic leukemia of childhood, <<PEDIATRIC BLOOD & CANCER>>, 2011; 56 (4): 544-550. [doi:10.1002/pbc.22787] [https://hdl.handle.net/10807/248342]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/248342
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