Objective A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative protein-sparing therapy.Summary Background Data The metabolic effect of postoperative protein-sparing therapy has been shown by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials.Methods Six hundred seventy-eight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (protein-sparing therapy group) or conventional therapy (control group). The patients were monitored for postoperative complications and mortality.Results The rate of major postoperative complications was similar in both groups (protein-sparing therapy group, 19.5%; control group, 20.9%; p = 0.66) as were the overall postoperative mortality rates (4.7% and 3.5%, respectively; p = 0.43).Conclusions The present study indicates that routine protein-sparing therapy for patients normonourished or mildly malnourished undergoing major abdominal surgery is not clinically justified.

Doglietto, G. B., Gallitelli, L., Pacelli, F., Bellantone, R. D. A., Malerba, M., Sgadari, A., Crucitti, F., Alfieri, S., Protein-Sparing Therapy Study, G., Protein-sparing therapy after major abdominal surgery: lack of clinical effects. Protein-Sparing Therapy Study Group, <<ANNALS OF SURGERY>>, 1996; 223 (4): 357-362. [doi:10.1097/00000658-199604000-00003] [https://hdl.handle.net/10807/248289]

Protein-sparing therapy after major abdominal surgery: lack of clinical effects. Protein-Sparing Therapy Study Group

Pacelli, Fabio;Bellantone, Rocco Domenico Alfonso;Sgadari, Antonio;Alfieri, Sergio;
1996

Abstract

Objective A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative protein-sparing therapy.Summary Background Data The metabolic effect of postoperative protein-sparing therapy has been shown by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials.Methods Six hundred seventy-eight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (protein-sparing therapy group) or conventional therapy (control group). The patients were monitored for postoperative complications and mortality.Results The rate of major postoperative complications was similar in both groups (protein-sparing therapy group, 19.5%; control group, 20.9%; p = 0.66) as were the overall postoperative mortality rates (4.7% and 3.5%, respectively; p = 0.43).Conclusions The present study indicates that routine protein-sparing therapy for patients normonourished or mildly malnourished undergoing major abdominal surgery is not clinically justified.
1996
Inglese
Doglietto, G. B., Gallitelli, L., Pacelli, F., Bellantone, R. D. A., Malerba, M., Sgadari, A., Crucitti, F., Alfieri, S., Protein-Sparing Therapy Study, G., Protein-sparing therapy after major abdominal surgery: lack of clinical effects. Protein-Sparing Therapy Study Group, <<ANNALS OF SURGERY>>, 1996; 223 (4): 357-362. [doi:10.1097/00000658-199604000-00003] [https://hdl.handle.net/10807/248289]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/248289
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