The possibility to use beta(-) decaying isotopes for radioguided surgery (RGS) has been recently proposed, and first promising tests on ex-vivo samples of Meningioma and intestinal Neuroendocrine Tumor (NET) have been published. This paper reports a study of the uptake of Ga-68-DOTATOC in pancreatic NETs (pNET s) in order to assess the feasibility of a new RGS approach using Y-90-DOTATOC. Tumor and healthy pancreas uptakes were estimated from Ga-68-DOTATOC PET/CT scans of 30 patients with pNETs. From the obtained SUVs (Standardised Uptake Value) and TNRs (Tumor Non tumor Ratio), an analysis algorithm relying on a Monte Carlo simulation of the detector has been applied to evaluate the performances of the proposed technique. Almost all considered patients resulted to be compatible with the application of beta(-)-RGS assuming to administer 1.5 MBq/kg of activity of Y-90-DOTATOC 24 h before surgery, and a sampling time of few seconds. In just 2 cases the technique would have required a mildly increased amount of activity or of sampling time. Despite a high physiological uptake of Ga-68-DOTATOC in the healthy pancreas, the proposed RGS technique promises to be effective. This approach allows RGS to find application also in pancreatic diseases, where traditional techniques are not viable.
Collamati, F., Maccora, D., Alfieri, S., Bocci, V., Cartoni, A., Collarino, A., Simoni, M. D., Fischetti, M., Fratoddi, I., Giordano, A., Mancini-Terracciano, C., Mirabelli, R., Morganti, S., Quero, G., Rotili, D., Scotognella, T., Solfaroli Camillocci, E., Traini, G., Venditti, I., Faccini, R., Radioguided surgery with β- radiation in pancreatic Neuroendocrine Tumors: a feasibility study, <<SCIENTIFIC REPORTS>>, 2020; 10 (1): 4015-N/A. [doi:10.1038/s41598-020-61075-2] [https://hdl.handle.net/10807/248236]