Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.
Spanu, T., De Angelis, G., Cipriani, M. C., Pedruzzi, B., D'Inzeo, T., Cataldo, M., Sganga, G., Tacconelli, E., In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli, <<ANTIMICROBIAL AGENTS AND CHEMOTHERAPY>>, 2012; 2012 (Agosto): 4516-4518. [doi:10.1128/AAC.00234-12] [http://hdl.handle.net/10807/24568]
In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli
Spanu, Teresa;De Angelis, Giulia;Cipriani, Maria Celeste;Pedruzzi, Barbara;D'Inzeo, Tiziana;Cataldo, Maria;Sganga, Gabriele;Tacconelli, Evelina
2012
Abstract
Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.
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