Recent findings demonstrate that loss of ERAAP, an endoplasmic reticulum aminopeptidase involved in antigen processing, plays a key role in stimulating anti-tumor innate and adaptive immune responses. We show that MHC class I molecules produced in the absence of ERAAP retain their capability of presenting antigens to CD8(+) T cells, but not of inhibiting NK cells.

Fruci, D., Locatelli, F., Cifaldi, L., ERAAP modulation: A possible novel strategy for cancer immunotherapy?, <<ONCOIMMUNOLOGY>>, 2012; 1 (1): 81-82. [doi:10.4161/onci.1.1.17828] [https://hdl.handle.net/10807/244439]

ERAAP modulation: A possible novel strategy for cancer immunotherapy?

Locatelli, Franco;
2012

Abstract

Recent findings demonstrate that loss of ERAAP, an endoplasmic reticulum aminopeptidase involved in antigen processing, plays a key role in stimulating anti-tumor innate and adaptive immune responses. We show that MHC class I molecules produced in the absence of ERAAP retain their capability of presenting antigens to CD8(+) T cells, but not of inhibiting NK cells.
2012
Inglese
Fruci, D., Locatelli, F., Cifaldi, L., ERAAP modulation: A possible novel strategy for cancer immunotherapy?, <<ONCOIMMUNOLOGY>>, 2012; 1 (1): 81-82. [doi:10.4161/onci.1.1.17828] [https://hdl.handle.net/10807/244439]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/244439
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