A quantification of the determinants of arterial hypoxemia was performed in 376 cardiorespiratory measurements obtained from 180 critically ill patients. Statistical analysis showed that pulmonary venous admixture (Qsp/Qt) could explain only 48% of the PaO2 variability in the sample of measurements taken (r2 = 0.48), while the effect of central venous O2 tension (PVO2) brought the total explained PaO2 variability up to 82% (total r2 = 0.82). These findings imply that pulmonary function is not the only determinant of PaO2; the PVO2-mediated effect of other cardiovascular and metabolic determinants must be recognized in the clinical setting.
Giovannini, I., Boldrini, G., Sganga, G., Castiglioni, G. C., Castagneto, M., Quantification of the determinants of arterial hypoxemia in critically ill patients, <<CRITICAL CARE MEDICINE>>, N/A; 11 (8): 644-645 [http://hdl.handle.net/10807/24336]
Quantification of the determinants of arterial hypoxemia in critically ill patients
Giovannini, Ivo;Boldrini, Giuseppe;Sganga, Gabriele;Castagneto, Marco
1983
Abstract
A quantification of the determinants of arterial hypoxemia was performed in 376 cardiorespiratory measurements obtained from 180 critically ill patients. Statistical analysis showed that pulmonary venous admixture (Qsp/Qt) could explain only 48% of the PaO2 variability in the sample of measurements taken (r2 = 0.48), while the effect of central venous O2 tension (PVO2) brought the total explained PaO2 variability up to 82% (total r2 = 0.82). These findings imply that pulmonary function is not the only determinant of PaO2; the PVO2-mediated effect of other cardiovascular and metabolic determinants must be recognized in the clinical setting.
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