Extracorporeal photopheresis (ECP) is broadly used in adults with cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), rejection of solid organ transplants, and a variety of autoimmune, cell-mediated diseases. The predominant use of ECP in children and adolescents is for treating GVHD. Children pose specific challenges to ECP, due to their unique physiology and to patient's size. Herein, we will focus on current clinical trials with ECP in children with GVHD, with an emphasis on technical and clinical issues that are peculiar to the paediatric setting. (C) 2014 Elsevier Ltd. All rights reserved.
Rutella, S., Valentini, C. G., Ceccarelli, S., Romano, M. T., Brescia, L. P., Milano, G. M., Locatelli, F., Extracorporeal photopheresis for paediatric patients experiencing graft-versus-host disease (GVHD), <<TRANSFUSION AND APHERESIS SCIENCE>>, 2014; 50 (3): 340-348. [doi:10.1016/j.transci.2014.04.004] [https://hdl.handle.net/10807/242598]
Extracorporeal photopheresis for paediatric patients experiencing graft-versus-host disease (GVHD)
Locatelli, Franco
2014
Abstract
Extracorporeal photopheresis (ECP) is broadly used in adults with cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), rejection of solid organ transplants, and a variety of autoimmune, cell-mediated diseases. The predominant use of ECP in children and adolescents is for treating GVHD. Children pose specific challenges to ECP, due to their unique physiology and to patient's size. Herein, we will focus on current clinical trials with ECP in children with GVHD, with an emphasis on technical and clinical issues that are peculiar to the paediatric setting. (C) 2014 Elsevier Ltd. All rights reserved.
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