Helicobacter pylori is a Gram-negative bacterium that is able to colonize the human stomach, whose high prevalence has a major impact on human health, due to its association with several gastric and extra-gastric disorders, including gastric cancer. The gastric microenvironment is deeply affected by H. pylori colonization, with consequent effects on the gastrointestinal microbiota, exerted via the regulation of various factors, including gastric acidity, host immune responses, antimicrobial peptides, and virulence factors. The eradication therapy required to treat H. pylori infection can also have detrimental consequences for the gut microbiota, leading to a decreased alpha diversity. Notably, therapy regimens integrated with probiotics have been shown to reduce the negative effects of antibiotic therapy on the gut microbiota. These eradication therapies combined with probiotics have also higher rates of eradication, when compared to standard treatments, and are associated with reduced side effects, improving the patient's compliance. In light of the deep impact of gut microbiota alterations on human health, the present article aims to provide an overview of the complex interaction between H. pylori and the gastrointestinal microbiota, focusing also on the consequences of eradication therapies and the effects of probiotic supplementation.

Fiorani, M., Tohumcu, E., Del Vecchio, L. E., Porcari, S., Cammarota, G., Gasbarrini, A., Ianiro, G., The Influence of Helicobacter pylori on Human Gastric and Gut Microbiota, <<ANTIBIOTICS>>, N/A; 12 (4): 765-N/A. [doi:10.3390/antibiotics12040765] [https://hdl.handle.net/10807/240224]

The Influence of Helicobacter pylori on Human Gastric and Gut Microbiota

Fiorani, Marcello;Del Vecchio, Livio Enrico;Porcari, Serena;Cammarota, Giovanni;Gasbarrini, Antonio;Ianiro, Gianluca
2023

Abstract

Helicobacter pylori is a Gram-negative bacterium that is able to colonize the human stomach, whose high prevalence has a major impact on human health, due to its association with several gastric and extra-gastric disorders, including gastric cancer. The gastric microenvironment is deeply affected by H. pylori colonization, with consequent effects on the gastrointestinal microbiota, exerted via the regulation of various factors, including gastric acidity, host immune responses, antimicrobial peptides, and virulence factors. The eradication therapy required to treat H. pylori infection can also have detrimental consequences for the gut microbiota, leading to a decreased alpha diversity. Notably, therapy regimens integrated with probiotics have been shown to reduce the negative effects of antibiotic therapy on the gut microbiota. These eradication therapies combined with probiotics have also higher rates of eradication, when compared to standard treatments, and are associated with reduced side effects, improving the patient's compliance. In light of the deep impact of gut microbiota alterations on human health, the present article aims to provide an overview of the complex interaction between H. pylori and the gastrointestinal microbiota, focusing also on the consequences of eradication therapies and the effects of probiotic supplementation.
2023
Inglese
Fiorani, M., Tohumcu, E., Del Vecchio, L. E., Porcari, S., Cammarota, G., Gasbarrini, A., Ianiro, G., The Influence of Helicobacter pylori on Human Gastric and Gut Microbiota, <<ANTIBIOTICS>>, N/A; 12 (4): 765-N/A. [doi:10.3390/antibiotics12040765] [https://hdl.handle.net/10807/240224]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/240224
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 10
social impact