Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

Gambaro, G., Fabris, A., Abaterusso, C., Cosaro, A., Ceol, M., Mezzabotta, F., Torregrossa, R., Tiralongo, E., Del Prete, D., D'Angelo, A., Anglani, F., Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology, <<CLINICAL CASES IN MINERAL AND BONE METABOLISM>>, 2008; 5 (2): 107-109 [http://hdl.handle.net/10807/23960]

Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Gambaro, Giovanni;
2008

Abstract

Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.
2008
Inglese
Gambaro, G., Fabris, A., Abaterusso, C., Cosaro, A., Ceol, M., Mezzabotta, F., Torregrossa, R., Tiralongo, E., Del Prete, D., D'Angelo, A., Anglani, F., Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology, <<CLINICAL CASES IN MINERAL AND BONE METABOLISM>>, 2008; 5 (2): 107-109 [http://hdl.handle.net/10807/23960]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/23960
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