The effects of combinations between eicosapentaenoic acid (EPA) and beta-carotene on cell growth and lipid peroxidation were investigated in human WiDr colon adenocarcinoma cells. EPA alone was able to inhibit the growth of WiDr cells in a dose- and time-dependent manner. Such an inhibition involved fatty acid peroxidation, as shown by the remarkable increase in the levels of Malondialdehyde (MDA) in EPA-treated cells. Beta-carotene was capable of reducing the growth inhibitory effects of EPA and the levels of MDA in a dose- and a time-dependent manner. In addition, EPA increased beta-carotene consumption in WiDr cells. This study provides evidence that beta-carotene can antagonize the effects of EPA on colon cancer cell growth and lipid peroxidation.

Palozza, P., Calviello, G., Maggiano, N., Lanza, P., Ranelletti, F. O., Bartoli, G., Beta-carotene antagonizes the effects of eicosapentaenoic acid on cell growth and lipid peroxidation in WiDr cells, <<FREE RADICAL BIOLOGY & MEDICINE>>, 2000; (28): 228-234 [http://hdl.handle.net/10807/23871]

Beta-carotene antagonizes the effects of eicosapentaenoic acid on cell growth and lipid peroxidation in WiDr cells

Palozza, Paola;Calviello, Gabriella;Ranelletti, Franco Oreste;
2000

Abstract

The effects of combinations between eicosapentaenoic acid (EPA) and beta-carotene on cell growth and lipid peroxidation were investigated in human WiDr colon adenocarcinoma cells. EPA alone was able to inhibit the growth of WiDr cells in a dose- and time-dependent manner. Such an inhibition involved fatty acid peroxidation, as shown by the remarkable increase in the levels of Malondialdehyde (MDA) in EPA-treated cells. Beta-carotene was capable of reducing the growth inhibitory effects of EPA and the levels of MDA in a dose- and a time-dependent manner. In addition, EPA increased beta-carotene consumption in WiDr cells. This study provides evidence that beta-carotene can antagonize the effects of EPA on colon cancer cell growth and lipid peroxidation.
Inglese
Palozza, P., Calviello, G., Maggiano, N., Lanza, P., Ranelletti, F. O., Bartoli, G., Beta-carotene antagonizes the effects of eicosapentaenoic acid on cell growth and lipid peroxidation in WiDr cells, <<FREE RADICAL BIOLOGY & MEDICINE>>, 2000; (28): 228-234 [http://hdl.handle.net/10807/23871]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/23871
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