Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E

Bartoli, G., Palozza, P., Marra, G., Armelao, F., Franceschelli, P., Luberto, C., Sgarlata, E., Piccioni, E., Anti, M., n-3 PUFA and alpha-tocopherol control of tumorcell proliferation., <<MOLECULAR ASPECTS OF MEDICINE>>, 1993; (14): 247-252 [http://hdl.handle.net/10807/23835]

n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.

Palozza, Paola;Piccioni, Elisabetta;Anti, Marcello
1993

Abstract

Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E
Inglese
Bartoli, G., Palozza, P., Marra, G., Armelao, F., Franceschelli, P., Luberto, C., Sgarlata, E., Piccioni, E., Anti, M., n-3 PUFA and alpha-tocopherol control of tumorcell proliferation., <<MOLECULAR ASPECTS OF MEDICINE>>, 1993; (14): 247-252 [http://hdl.handle.net/10807/23835]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/23835
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact