This is the first report demonstrating a relationship between apoptosis induction and changes of intracellular redox potential in the growth-inhibitory effects of high concentrations of beta-carotene in a tumor cell line. beta-Carotene inhibited the growth of human WiDr colon adenocarcinoma cells in a dose- and time-dependent manner, induced apoptosis, and blocked Bcl-2 expression. These effects were accompanied by an enhanced production of intracellular reactive oxygen species (ROS). The addition of the antioxidant alpha-tocopherol blocked both the pro-oxidant and the growth-inhibitory effects of the carotenoid. These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties

Palozza, P., Calviello, G., Serini, S., Maggiano, N., Lanza, P., Ranelletti, F. O., Bartoli, G., Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells, <<FREE RADICAL BIOLOGY & MEDICINE>>, 2001; (30): 1000-1007 [http://hdl.handle.net/10807/23832]

Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells

Palozza, Paola;Calviello, Gabriella;Serini, Simona;Ranelletti, Franco Oreste;
2001

Abstract

This is the first report demonstrating a relationship between apoptosis induction and changes of intracellular redox potential in the growth-inhibitory effects of high concentrations of beta-carotene in a tumor cell line. beta-Carotene inhibited the growth of human WiDr colon adenocarcinoma cells in a dose- and time-dependent manner, induced apoptosis, and blocked Bcl-2 expression. These effects were accompanied by an enhanced production of intracellular reactive oxygen species (ROS). The addition of the antioxidant alpha-tocopherol blocked both the pro-oxidant and the growth-inhibitory effects of the carotenoid. These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties
Inglese
Palozza, P., Calviello, G., Serini, S., Maggiano, N., Lanza, P., Ranelletti, F. O., Bartoli, G., Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells, <<FREE RADICAL BIOLOGY & MEDICINE>>, 2001; (30): 1000-1007 [http://hdl.handle.net/10807/23832]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/23832
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