We have studied the T-cell-mediated response to the major allergen of cow's milk, in a group of newborns at risk of developing cow's milk allergy, and in a control group. Before any atopic status has developed, we observe beta-lactoglobulin-specific proliferation only in the group at risk for food-related allergies. In this group, the capability to proliferate is not due to placental transmission of `factors' from allergic mothers. The recognition of the tested beta-lactoglobulin peptides does not show major differences between the responder and nonresponder populations. In the responder population, the response to p145-161 appears linked to a primary response to ovalbumin, another frequent food allergen. On the basis of our findings, we propose a model in which development of allergic diseases is linked to an alteration of T-cell activation through the engagement by the antigen; the HLA phenotype determines the allergen(s) involved, and other genetic or environmental factors dictate the clinical characteristics of the disease.

Piastra, M., Stabile, A., Fioravanti, G., Castagnola, M., Pani, G., Ria, F., CORD-BLOOD MONONUCLEAR CELL RESPONSIVENESS TO BETA-LACTOGLOBULIN - T-CELL ACTIVITY IN ATOPY-PRONE AND NON-ATOPY-PRONE NEWBORNS, <<INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY>>, 1994; 104 (4): 358-365 [http://hdl.handle.net/10807/23685]

CORD-BLOOD MONONUCLEAR CELL RESPONSIVENESS TO BETA-LACTOGLOBULIN - T-CELL ACTIVITY IN ATOPY-PRONE AND NON-ATOPY-PRONE NEWBORNS

Piastra, Marco;Stabile, Achille;Castagnola, Massimo;Pani, Giovambattista;Ria, Francesco
1994

Abstract

We have studied the T-cell-mediated response to the major allergen of cow's milk, in a group of newborns at risk of developing cow's milk allergy, and in a control group. Before any atopic status has developed, we observe beta-lactoglobulin-specific proliferation only in the group at risk for food-related allergies. In this group, the capability to proliferate is not due to placental transmission of `factors' from allergic mothers. The recognition of the tested beta-lactoglobulin peptides does not show major differences between the responder and nonresponder populations. In the responder population, the response to p145-161 appears linked to a primary response to ovalbumin, another frequent food allergen. On the basis of our findings, we propose a model in which development of allergic diseases is linked to an alteration of T-cell activation through the engagement by the antigen; the HLA phenotype determines the allergen(s) involved, and other genetic or environmental factors dictate the clinical characteristics of the disease.
1994
Inglese
Piastra, M., Stabile, A., Fioravanti, G., Castagnola, M., Pani, G., Ria, F., CORD-BLOOD MONONUCLEAR CELL RESPONSIVENESS TO BETA-LACTOGLOBULIN - T-CELL ACTIVITY IN ATOPY-PRONE AND NON-ATOPY-PRONE NEWBORNS, <<INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY>>, 1994; 104 (4): 358-365 [http://hdl.handle.net/10807/23685]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/23685
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