Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.

Romagnoli, C., Bersani, I., Rubortone, S. A., Lacerenza, S., De Carolis, M. P., Current evidence on the safety profile of NSAIDs for the treatment of PDA., <<THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE>>, 2011; (Novembre): 10-13 [http://hdl.handle.net/10807/23604]

Current evidence on the safety profile of NSAIDs for the treatment of PDA.

Romagnoli, Costantino;Bersani, Iliana;Lacerenza, Serafina;De Carolis, Maria Pia
2011

Abstract

Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.
Inglese
Romagnoli, C., Bersani, I., Rubortone, S. A., Lacerenza, S., De Carolis, M. P., Current evidence on the safety profile of NSAIDs for the treatment of PDA., <<THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE>>, 2011; (Novembre): 10-13 [http://hdl.handle.net/10807/23604]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/23604
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