Aging is a complex and multifactorial process resulting, at least partly, from the generation and accrual of damage in the setting of reduced resilience. A plethora of environmental and endogenous factors (i.e., exposomes) contribute to the mismatch between cellular damage and reparative capacity. Exposome constituents and their biological targets are only partially known. Nevertheless, core biological mechanisms, collectively known as the hallmarks of aging, have been identified and are actively investigated to develop therapeutics against chronic degenerative conditions.
Picca, A., Marzetti, E., Advancements in Anti-Aging Treatment Development, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2023; 24 (10): 1-2. [doi:10.3390/ijms24108515] [https://hdl.handle.net/10807/235590]
Advancements in Anti-Aging Treatment Development
Marzetti, Emanuele
2023
Abstract
Aging is a complex and multifactorial process resulting, at least partly, from the generation and accrual of damage in the setting of reduced resilience. A plethora of environmental and endogenous factors (i.e., exposomes) contribute to the mismatch between cellular damage and reparative capacity. Exposome constituents and their biological targets are only partially known. Nevertheless, core biological mechanisms, collectively known as the hallmarks of aging, have been identified and are actively investigated to develop therapeutics against chronic degenerative conditions.
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