Objectives To investigate the safety and tolerability of COVID-19 vaccines in people with epilepsy (PwE). Methods In this multicentric observational cohort study, we recruited adult patients (age > 18 years old) with epilepsy who attended the Outpatient Epilepsy Clinic from 1st July to 30th October 2021. We administered to the patients a structured questionnaire and interview on demographic and epilepsy characteristics, current treatment, previous SARS-CoV-2 infection, vaccine characteristics, post-vaccine seizure relapse, other side effect, variation of sleep habits, caffeine, or alcohol intake. Seizure frequency worsening was defined as a ratio between mean monthly frequency post-vaccination and mean monthly frequency pre-vaccination superior to 1. Patients were categorized in two groups: patients with seizure frequency worsening (WORSE) and patients with seizure stability (STABLE). Results A total of 358 people participated with a mean age of 47.46 +/- 19.04. Focal seizure (79.1%), generalized epilepsy (20.4%), and unknown types of epilepsy (0.5%) were detected among participants. In total, 31 (8.7%) people expressed that they were not willing to receive a COVID-19 vaccine; 302 patients (92.35%) did not experience an increase in the seizure frequency (STABLE-group) whereas 25 patients (7.65%) had a seizure worsening (WORSE-group). Post-vaccine seizures occurred mainly in the 7 days following the administration of the vaccine. Patients in the WORSE-group were treated with a mean higher number of anti-seizure medication (ASMs) (p = 0.003) and had a higher pre-vaccine seizure frequency (p = 0.009) compared with patients in the STABLE-group. Drug-resistant epilepsy was also associated with seizure worsening (p = 0.01). One-year pre-vaccination seizure frequency pattern demonstrated that patients in the WORSE-group had a higher frequency pattern (p < 0.001). Multivariate analysis of the vaccinated group showed that only the seizure frequency pattern (confidence interval [CI] = 1.257-2.028; p < 0.001) was significantly associated with seizure worsening. Conclusion In our cohort of vaccinated PwE, only a little percentage had a transient short-term increase of seizure frequency. The present study demonstrates that COVID-19 vaccines have a good safety and tolerability profile in the short term in PwE.

Romozzi, M., Rollo, E., Quintieri, P., Dono, F., Evangelista, G., Consoli, S., Veleno, L., Anzellotti, F., Calvello, C., Costa, C., Servidei, S., Calabresi, P., Vollono, C., Impact of COVID-19 vaccine on epilepsy in adult subjects: an Italian multicentric experience, <<NEUROLOGICAL SCIENCES>>, 2022; 43 (8): 4627-4634. [doi:10.1007/s10072-022-06100-0] [https://hdl.handle.net/10807/235231]

Impact of COVID-19 vaccine on epilepsy in adult subjects: an Italian multicentric experience

Romozzi, Marina;Rollo, Eleonora;Servidei, Serenella;Calabresi, Paolo;Vollono, Catello
2022

Abstract

Objectives To investigate the safety and tolerability of COVID-19 vaccines in people with epilepsy (PwE). Methods In this multicentric observational cohort study, we recruited adult patients (age > 18 years old) with epilepsy who attended the Outpatient Epilepsy Clinic from 1st July to 30th October 2021. We administered to the patients a structured questionnaire and interview on demographic and epilepsy characteristics, current treatment, previous SARS-CoV-2 infection, vaccine characteristics, post-vaccine seizure relapse, other side effect, variation of sleep habits, caffeine, or alcohol intake. Seizure frequency worsening was defined as a ratio between mean monthly frequency post-vaccination and mean monthly frequency pre-vaccination superior to 1. Patients were categorized in two groups: patients with seizure frequency worsening (WORSE) and patients with seizure stability (STABLE). Results A total of 358 people participated with a mean age of 47.46 +/- 19.04. Focal seizure (79.1%), generalized epilepsy (20.4%), and unknown types of epilepsy (0.5%) were detected among participants. In total, 31 (8.7%) people expressed that they were not willing to receive a COVID-19 vaccine; 302 patients (92.35%) did not experience an increase in the seizure frequency (STABLE-group) whereas 25 patients (7.65%) had a seizure worsening (WORSE-group). Post-vaccine seizures occurred mainly in the 7 days following the administration of the vaccine. Patients in the WORSE-group were treated with a mean higher number of anti-seizure medication (ASMs) (p = 0.003) and had a higher pre-vaccine seizure frequency (p = 0.009) compared with patients in the STABLE-group. Drug-resistant epilepsy was also associated with seizure worsening (p = 0.01). One-year pre-vaccination seizure frequency pattern demonstrated that patients in the WORSE-group had a higher frequency pattern (p < 0.001). Multivariate analysis of the vaccinated group showed that only the seizure frequency pattern (confidence interval [CI] = 1.257-2.028; p < 0.001) was significantly associated with seizure worsening. Conclusion In our cohort of vaccinated PwE, only a little percentage had a transient short-term increase of seizure frequency. The present study demonstrates that COVID-19 vaccines have a good safety and tolerability profile in the short term in PwE.
2022
Inglese
Romozzi, M., Rollo, E., Quintieri, P., Dono, F., Evangelista, G., Consoli, S., Veleno, L., Anzellotti, F., Calvello, C., Costa, C., Servidei, S., Calabresi, P., Vollono, C., Impact of COVID-19 vaccine on epilepsy in adult subjects: an Italian multicentric experience, <<NEUROLOGICAL SCIENCES>>, 2022; 43 (8): 4627-4634. [doi:10.1007/s10072-022-06100-0] [https://hdl.handle.net/10807/235231]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/235231
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