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IRIS PubliCatt
The genetic make-up of an individual contributes to the susceptibility
and response to viral infection. Although environmental, clinical and
social factors have a role in the chance of exposure to SARS-CoV-2 and
the severity of COVID-19(1,2), host genetics may also be important.
Identifying host-specific genetic factors may reveal biological
mechanisms of therapeutic relevance and clarify causal relationships of
modifiable environmental risk factors for SARS-CoV-2 infection and
outcomes. We formed a global network of researchers to investigate the
role of human genetics in SARS-CoV-2 infection and COVID-19 severity.
Here we describe the results of three genome-wide association
meta-analyses that consist of up to 49,562 patients with COVID-19 from
46 studies across 19 countries. We report 13 genome-wide significant
loci that are associated with SARS-CoV-2 infection or severe
manifestations of COVID-19. Several of these loci correspond to
previously documented associations to lung or autoimmune and
inflammatory diseases(3-7). They also represent potentially actionable
mechanisms in response to infection. Mendelian randomization analyses
support a causal role for smoking and body-mass index for severe
COVID-19 although not for type II diabetes. The identification of novel
host genetic factors associated with COVID-19 was made possible by the
community of human genetics researchers coming together to prioritize
the sharing of data, results, resources and analytical frameworks. This
working model of international collaboration underscores what is
possible for future genetic discoveries in emerging pandemics, or indeed
for any complex human disease.
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Mapping the human genetic architecture of COVID-19
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J. and Algera;Anne Geke and van Baarle;Frank and Bos;Lieuwe and Botta;Michela and de Bruin;Sanne and Bulle;Esther and Dongelmans;Dave and Elbers;Paul and Fleuren;Lucas and Girbes;Armand and Hagens;Laura and Heunks;Leo and Horn;Janneke and van Mourik;Niels and Paulus;Frederique and Raasveld;Jorinde and Schultz;Marcus J. and Smit;Marry and Teunissen;Charlotte and Thoral;Patrick and de Vries;Heder and Wiersinga;W. Joost and van Agtmael;Michiel and Bomers;Marije and de Brabander;Justin and de Bree;Godelieve and Chouchane;Osoul and Geerlings;Suzanne and Goorhuis;Bram and Grobusch;Martin P. and Harris;Vanessa and Hermans;Sabine M. and Hovius;Joppe W. and Nellen;Jeannine and Peters;Edgar and van der Poll;Tom and Prins;Jan M. and Reijnders;Tom and Schinkel;Michiel and Schuurman;Alex and Sigaloff;Kim and Stijnis;Cornelis S. and Tsonas;Anissa and van der Valk;Marc and van Vugt;Michele and Zwinderman;A. H. Koos and Bax;Diane and Cloherty;Alex and Geijtenbeek;Theo and Hafkamp;Florianne and Preckel;Bennedikt and Bogaard;Harm Jan and Bonta;I;Peter and Nossent;Esther J. and Bugiani;Marianna and Geerts;Bart and Hollmann;Markus and Veelo;Denise and Hamann;Jorg and Hemke;Robert and de Jong;Menno D. and Stilma;Willemke and Wouters;Dorien and Minnaar;Rene P. and Kromhout;Adrie and van Uffelen;Kees W. J. and Wolterman;Ruud A. and Roberts;Genevieve and Park;Danny and Ball;Catherine A. and Coignet;Marie and McCurdy;Shannon and Knight;Spencer and Partha;Raghavendran and Rhead;Brooke and Zhang;Miao and Berkowitz;Nathan and Gaddis;Michael and Noto;Keith and Ruiz;Luong and Pavlovic;Milos and Hong;Eurie L. and Rand;Kristin and Girshick;Ahna and Guturu;Harendra and Baltzell;Asher Haug and Georges;Michel and Melo;Sofia and Jacques;Nicolas and Di Valentin;Emmanuel and Giroule;Francois and Collignon;Alice and Radermecker;Coraline and Lebrun;Marielle and Peree;Helene and Latour;Samuel and Barada;Olivia and Sanchez;Judit and Meunier;Margot and Mariavelle;Emeline and Anania;Sandy and Gazon;Helene and Mni;Myriam and Wery;Marie and Belhaj;Yasmine and Guntz;Julien and Jadot;Laurent and Claassen;Sabine and Beguin;Yves and Gofflot;Stephanie and El Kandoussi;Kamilia and Thonon;Raphael and Bouysran;Youssef and Busson;Adeline and Peyrassol;Xavier and Wilkin;Francoise and Pichon;Bruno and Smits;Guillaume and Vandernoot;Isabelle and Goffard;Jean-Christophe and Moutschen;Michel and Misset;Benoit and Darcis;Gilles and Guiot;Julien and Azarzar;Samira and Dellot;Patricia and Bertrand;Axelle and Parzibut;Gilles and Clarinval;Mathilde and Moermans;Catherine and Malaise;Olivier and Huynen;Pascale and Mesdagh;Alyssia and Josse;Claire and Boujemla;Bouchra and Juszczak;Danusia and Fadeur;Marjorie and Camby;Severine and Meuris;Christelle and Thys;Marie and Jacques;Jessica and Henket;Monique and Leonard;Philippe and Frippiat;Frederic and Giot;Jean-Baptiste and Sauvage;Anne-Sophie and Von Frenckell;Christian and Staderoli;Alicia and Lambermont;Bernard and Louis;Edouad and Afilalo;Marc and Oliveira;Maureen and Brenner;Bluma and Brassard;Nathalie and Durand;Madeleine and Chasse;Michael and Kaufmann;Daniel E. and Schurr;Erwin and Davis;Lea K. and Cox;Nancy J. and Below;Jennifer E. and Sealock;Julia M. and Faucon;Annika B. and Shuey;Megan M. and Polikowsky;Hannah G. and Petty;Lauren E. and Shaw;Douglas M. and Chen;Hung-Hsin and Zhu;Wanying and Ludwig;Kerstin U. and Schroeder;Julia and Rolker;Selina and Nothen;Markus M. and Fazaal;Julia and Maj;Carlo and Keitel;Verena and Jensen;Bjorn-Erik Ole and Feldt;Torsten and Knopp;Lisa and Kurth;Ingo and Eggermann;Thomas and Marx;Nikolaus and Dreher;Michael and Pink;Isabell and Cornberg;Markus and Illig;Thomas and Volland;Sonja and Lehmann;Clara and Schommers;Philipp and Augustin;Max and Rybniker;Jan and Koehler;Philipp and Cornely;Oliver A. and Altmuller;Janine and Berger;Marc M. and Brenner;Thorsten and Hinney;Anke and Witzke;Oliver and Bals;Robert and Herr;Christian and Ludwig;Nicole and Walter;Jorn and Fuchsberger;Christian and Pattaro;Cristian and De Grandi;Alessandro and Pramstaller;Peter and Emmert;David and Melotti;Roberto and Foco;Luisa and Mascalzoni;Deborah and Gogele;Martin and Domingues;Francisco and Hicks;Andrew and Gignoux;Christopher R. and Wicks;Stephen J. and Crooks;Kristy and Barnes;Kathleen C. and Daya;Michelle and Shortt;Jonathan and Rafaels;Nicholas and Chavan;Sameer and Goldstein;David B. and Kiryluk;Krzysztof and Sengupta;Soumitra and Menon;Amritha and So;Yat S. and Chung;Wendy and Reilly;Muredach P. and Khan;Atlas and Wang;Chen and Gharavi;Ali G. and Shang;Ning and O'Byrne;Sheila M. and Nandakumar;Renu and Povysil;Gundula and Bhardwaj;Nitin and Ionita-Laza;Iuliana and Hod;Eldad and Pendrick;Danielle and Park;Soo-Kyung and Kim;Hyung-Lae and Kang;Chang Kyung and Park;Wan Beom and Lee;Hyo-Jung and Song;Kyoung-Ho and Ham;Sin Young and Jung;Jongtak and Kim;Eu Suk and Bin Kim;Hong and Yoon;Kyung Jae and Paik;Nam-Jong and Seok;Woojin and Yoon;Heejun and Joo;Eun-Jeong and Chang;Yoosoo and Ryu;Seungho and Park;Jeong Su and Park;Kyoung Un and Ellinghaus;David and Degenhardt;Frauke and Juzenas;Simonas and Tran;Florian and Rosenstiel;Philip and Schreiber;Stefan and Franke;Andre and Wacker;Eike Matthias and Uellendahl-Werth;Florian and ElAbd;Hesham and Wienbrandt;Lars and Ruhlemann;Malte Christoph and Wendorff;Mareike and Tanck;Anja and Gassner;Christoph and Hemmrich-Stanisak;Georg and Kassens;Jan and Basso;Maria E. Figuera and Schulzky;Martin and Wittig;Braun, Michael Reto;Nicole and Wesse;Tanja and Albrecht;Wolfgang and Yi;Xiaoli and Nebel;Almut and Peschuck;Anna and May;Sandra and Karina;Banasik and Brunak;Soren and Caceres;Mario and Lerga-Jaso;Jon and Lenz;Tobias L. and Teles;Ana and Azuure;Clinton and Ozer;Onur and Albillos;Agustin and Mateos;Beatriz and Mesonero;Francisco and Tellez;Luis and Rodriguez-Gandia;Miguel and Bujanda;Luis and Banales;Jesus M. and Romero-Gomez;Manuel and Buti;Maria and Maya-Miles;Douglas and Garcia-Etxebarria;Koldo and Izquierdo-Sanchez;Laura and Rodrigues;Pedro M. and Rodriguez-Frias;Francisco and Riveiro-Barciela;Mar and Julia;Antonio and Palom;Adriana and Marsal;Sara and Heidecker;Bettina and Kurth;Florian and Sander;Leif Erik and Mayer;Alena and Braun;Alice and Skurk;Carsten and Thibeault;Charlotte and Helbig;Elisa T. and Kraft;Julia and Lippert;Lena J. and Suwalski;Phillip and Ripke;Stephan and Poller;Wolfgang and Wang;Xiaomin and Karadeniz;Zehra and Garcia;Federico and Quero;Jose Hernandez and Chueca;Natalia and Cejudo;Trinidad Gonzalez and Hanses;Frank and Wilfling;Sibylle and Zoller;Heinz and Schaefer;Benedikt and Holter;Jan C. and Hov;Johannes R. and Karlsen;Tom H. and Folseraas;Trine and Holten;Aleksander Rygh and Dyrhol-Riise;Anne Ma and Tonby;Kristian and Lind;Andreas and Muller;Fredrik and Dudman;Susanne and Grimsrud;Marit M. and Fernandez;Javier and Ferrando;Carlos and Reverter;Enric and Badia;Joan Ramon and Hernandez-Tejero;Maria and Castro;Pedro and de Cid;Rafael and Nolla;Anna Carreras and Cortes;Beatriz and Galvan-Femenia;Ivan and Blay;Natalia and Farre;Xavier and Asselta;Rosanna and Duga;Stefano and Mantovani;Alberto and Protti;Alessandro and Aghemo;Alessio and Lleo;Ana and Voza;Antonio and Azzolini;Elena and Paraboschi;Elvezia Maria and My;Ilaria and Cecconi;Maurizio and Tentorio;Paolo and Badalamenti;Salvatore and Bombace;Sara and Cappadona;Claudio and Rimoldi;Valeria and Goerg;Siegfried and Hehr;Ute and Perez;Emma F. and Lenning;Ole Bernt and Vadla;May Sissel and Myhre;Ronny and Ortiz;Aaron Blandino and de Pablo;Raul and Chercoles;Adolfo Garrido and Nafria-Jimenez;Beatriz and Ruiz;Agustin and Hernandez;Isabel and de Rojas;Itziar and Marquie;Marta and Boada;Merce and Prati;Daniele and Baselli;Guido and Valenti;Luca and Cherubini;Alessandro and Muscatello;Antonio and Hu;Cinzia and Bianco;Cristiana and Galimberti;Daniela and Scarpini;Elio and Ceriotti;Ferruccio and Lamorte;Giuseppe and Terranova;Leonardo and Ostadreza;Mahnoosh and Zanella;Alberto and Bandera;Alessandra and Gori;Andrea and Fracanzani;Anna Ludovica and Pesenti;Antonio and Paccapelo;Cinzia and Martinelli-Boneschi;Filippo and Peyvandi;Flora and Blasi;Francesco and Grasselli;Giacomo and Costantino;Giorgio and Santoro;Luigi and Scudeller;Luigia and Carrabba;Maria and Baldini;Marina and Miozzo;Monica and Montano;Nicola and Gualtierotti;Roberta and Pelusi;Serena and Bosari;Silvano and Aliberti;Stefano and Monzani;Valter and Invernizzi;Pietro and Gerussi;Alessio and Milani;Chiara and Ramirez;Alfredo and Andrade;Victor and Barreira;Ana and Kildal;Anders Benjamin and Gluck;Andreas and Bahmer;Thomas and Latiano;Anna and Palmieri;Orazio and Rando-Segura;Ariadna and Roade;Luisa and Solier;Aurora and Jimenez;David and Nieto;Rosa and Bellinghausen;Carla and Quereda;Carmen and Navas;Enrique and Spinner;Christoph D. and Schneider;Jochen and Lange;Christoph and Heyckendorf;Jan and Sancho;Cristina and Intxausti;Maider and Hoff;Dag Arne Lihaug and Afset;Jan Egil and Haider;Sammra and Pestana;David and Toapanta;David and Urrechaga;Eloisa and Espana;Pedro P. and Pontali;Emanuele and Garbarino;Lucia and Mazzocco;Michela and Arana;Eunate and Ayo;Natale Imaz and Sanchez;Felix Garcia and Malvestiti;Francesco and Pezzoli;Gianni and Neb;Holger and D'Amato;Mauro and Goikoetxea;Josune and Muller;Karl Erik and Heggelund;Lars and Gaede;I;Karoline and Sumoy;Lauro and Kogevinas;Manolis and Garcia-Aymerich;Judith and Castano-Vinyals;Gemma and Dobano;Carlota and Moreno;Victor and Gutierrez-Stampa;Maria A. and Vehreschild;Maria J. G. T. and Khodamoradi;Yascha and Castoldi;Massimo and Zheng;Tenghao and Seilmaier;Michael J. and Martinez;Nilda and Hoffmann;Per and Heilmann-Heimbach;Stefanie and Bacher;Petra and Ciesek;Sandra and Landmesser;Ulf and Skogen;Vegard and Calderon;Enrique J. and Medrano;Francisco J. and Delgado;Juan and Morilla;Ruben and Friaza;Vicente and Gudbjartsson;Daniel F. and Stefansson;Kari and Sulem;Patrick and Sveinbjornsson;Gardar and Melsted;Pall and Norddahl;Gudmundur and Moore;Kristjan Helgi Swerford and Thorsteinsdottir;Unnur and Holm;Hilma and Bernardo;David and Ampuero;Javier and Rello;Silvia Rojo and Magi;Reedik and Milani;Lili and Metspalu;Andres and Laisk;Triin and Lall;Kristi and Lepamets;Maarja and Esko;Tonu and Reimann;Ene and Alavere;Helene and Metsalu;Kristjan and Puusepp;Mairo and Naaber;Paul and Laane;Edward and Pesukova;Jaana and Peterson;Part and Kisand;Kai and Tabri;Jekaterina and Allos;Raili and Hensen;Kati and Starkopf;Joel and Ringmets;Inge and Tamm;Anu and Kallaste;Anne and Kristiansson;Kati and Koskelainen;Sami and Perola;Markus and Rivolta;Carlo and Quinodoz;Mathieu and Kamdar;Dhryata and Bochud;Pierre-Yves and Bibert;Stephanie and Boillat;Noemie and Nussle;Semira Gonseth and Albrich;Werner and Suh;Noemie and Neofytos;Dionysios and Erard;Veronique and Voide;Cathy and Bochud;P. Y. and Rivolta;C. and Bibert;S. and Quinodoz;M. and Kamdar;D. and Neofytos;D. and Erard;V and Voide;C. and Friolet;R. and Vollenweider;P. and Pagani;J. L. and Oddo;M. and zu Bentrup;F. Meyer and Conen;A. and Clerc;O. and Marchetti;O. and Guillet;A. and Guyat-Jacques;C. and Foucras;S. and Rime;M. and Chassot;J. and Jaquet;M. and Viollet;R. Merlet and Lannepoudenx;Y. and Portopena;L. and Desgranges;F. and Filippidis;P. and Guery;B. and Haefliger;D. and Kampouri;E. E. and Manuel;O. and Munting;A. and Papadimitriou-Olivgeris;M. and Regina;J. and Rochat-Stettler;L. and Suttels;V and Tadini;E. and Tschopp;J. and Van Singer;M. and Viala;B. and Boillat-Blanco;N. and Brahier;T. and Hugli;O. and Meuwly;J. Y. and Pantet;O. and Pumarola;Tomas and Nussle;S. Gonseth and Bochud;M. and D'Acremont;V and Younes;S. Estoppey and Albrich;W. C. and Suh;N. and Cerny;A. and O'Mahony;L. and Frischknecht;M. and Kleger;G-R and Filipovic;M. and Kahlert;C. R. and Wozniak;H. and Negro;T. Rochat and Pugin;J. and Bouras;K. and Knapp;C. and Egger;T. and Perret;A. and Montillier;P. and di Bartolomeo;C. and Barda;B. and Carreras;Anna and Mercader;Josep Maria and Guindo-Martinez;Marta and Torrents;David and Gori;Marco and Picchiotti;Nicola and Mondelli;Mario Umberto and Bruno;Raffaele and Ludovisi;Serena and Castelli;Francesco and Quiros-Roldan;Eugenia and Degli Antoni;Melania and Vaghi;Massimo and Rusconi;Stefano and Riva;Agostino and Siano;Matteo and Gabrieli;Arianna and Fabbiani;Massimiliano and Rossetti;Barbara and Rancan;Ilaria and Bargagli;Elena and Bergantini;Laura and D'Alessandro;Miriana and Cameli;Paolo and Bennet;David and Franchi;Federico and Anedda;Federico and Marcantonio;Simona and Scolletta;Sabino and Mazzei;Maria Antonietta and Guerrini;Susanna and Cantarini;Luca and Conticini;Edoardo and Frediani;Bruno and Tacconi;Danilo and Spertilli;Chiara and Feri;Marco and Donati;Alice and Scala;Raffaele and Guidelli;Luca and Spargi;Genni and Corridi;Marta and Nencioni;Cesira and Croci;Leonardo and Bandini;Maria and Spagnesi;Maurizio and Piacentini;Paolo and Desanctis;Elena and Cappelli;Silvia and Caldarelli;Gian Piero and Canaccini;Anna and Verzuri;Agnese and Anemoli;Valentina and Ognibene;Agostino and Pancrazi;Alessandro and Lorubbio;Maria and Monforte;Antonella D'Arminio and Merlini;Esther and Miraglia;Federica Gaia and Girardis;Massimo and Busani;Stefano and Venturelli;Sophie and Antinori;Andrea and Emiliozzi;Arianna and Vergori;Alessandra and Francisci;Daniela and Schiaroli;Elisabetta and Paciosi;Francesco and Scotton;Pier Giorgio and Andretta;Francesca and Panese;Sandro and Scaggiante;Renzo and Gatti;Francesca and Della Monica;Matteo and Piscopo;Carmelo and Capasso;Mario and Russo;Roberta and Andolfo;Immacolata and Iolascon;Achille and Merla;Fiorentino, Giuseppe;Giuseppe and Castori;Marco and Carella;Massimo and Aucella;Filippo and Di Biagio;Antonio and Bassetti;Matteo and Masucci;Luca and Guarnaccia;Alessandra and Sanguinetti;Maurizio and Valente;Serafina and De Vivo;Oreste and Mandala;Marco and Giorli;Alessia and Salerni;Lorenzo and Zucchi;Patrizia and Parravicini;Pierpaolo and Giannattasio;Ferdinando and Trotta;Tullio and Coiro;Gabriella and Mussini;Cristina and Bosio;Giancarlo and Martinelli;Enrico and Tavecchia;Luisa and Belli;Mary Ann and Mancarella;Sandro and Crotti;Lia and Parati;Gianfranco and Rizzi;Marco and Maggiolo;Franco and Ripamonti;Diego and La Rovere;Maria Teresa and Sarzi-Braga;Simona and Bussotti;Maurizio and Ravaglia;Sabrina and Sabrina;Ravaglia and Artuso;Rosangela and Perrella;Antonio and Romani;Davide and Bergomi;Paola and Catena;Emanuele and Colombo;Riccardo and Dei;Simona and Tanfoni;Marco and Sanarico;Maurizio and Raimondi;Francesco and Biscarini;Filippo and Stella;Alessandra and Bergomi;Mattia and Vecchia;Marco and Mantovani;Stefania and Zanella;Isabella and Cossarizza;Andrea and Parisi;Saverio Giuseppe and Baratti;Stefano and Squeo;Gabriella Maria and Raggi;Pamela and Marciano;Carmen and Perna;Rita and Menatti;Elisabetta and Lena;Fabio and Gabbi;Chiara and Bachetti;Tiziana and Suardi;Claudia and Botta;Giordano and Di Domenico;Paolo and Trembath;Richard C. and Huang;Qin Qin and Martin;Hilary C. and Mason;Dan and Wright;John and Finer;Sarah and Akhtar;Shaheen and Anwar;Mohammad and Arciero;Elena and Ashraf;Samina and Breen;Gerome and Chung;Raymond and Curtis;Charles J. and Chowdhury;Maharun and Colligan;Grainne and Deloukas;Panos and Durham;Ceri and Griffiths;Chris and Hurles;Matt and Hussain;Shapna and Islam;Kamrul and Khan;Ahsan and Khan;Amara and Lavery;Cath and Lee;Sang Hyuck and Lerner;Robin and MacArthur;Daniel and MacLaughlin;Bev and Martin;Hilary and Miah;Shefa and Newman;Bill and Safa;Nishat and Tahmasebi;Farah and Griffiths;Christopher J. and Smith;V;Albert and Boughton;Andrew P. and Li;Kevin W. and LeFaive;Jonathon and Annis;Aubrey and Zollner;Sebastian and Wang;Jiongming and Beck;Andrew and Jannes;Cinthia E. and Krieger;Jose E. and Pereira;Alexandre C. and Velho;Mariliza and Marques;Emanuelle and Lima;Isabella Ramos and Tada;Mauricio Teruo and Valino;Karina and McCarthy;Mark and Rosenberger;Carrie and Chang;Diana and Hammer;Christian and Hunkapiller;Julie and Mahajan;Anubha and Pendergrass;Sarah and Sucheston-Campbell;Lara and Yaspan;Brian and Lee;Jong Eun and Lee;Hyun Soo and Shin;Eunsoon and Jang;Hye Yoon and Kim;Sunmie and Kym;Sungmin and Kim;Yeon-Sook and Jeong;Hyeongseok and Alegria;Ana and Kwon;Ki Tae and Kim;Shin-Woo and Kim;Jin Yong and Jang;Young Rock and Kim;Hyun Ah and Lee;Ji Yeon and Lee;Jeong Eun and Lee;Shinwon and Choe;Kang-Won and Kang;Yu Min and Ha Jee;Sun and Jung;Keum Ji and Parikh;Victoria and Wheeler;Matthew and Dalton;Karen and Christle;Jeff and Gorzynski;John and de Jong;Hannah and Sutton;Shirley and Youlton;Nathan and Joshi;Ruchi and Jimenez-Morales;David and Hughes;Christopher and Amar;David and Hershman;Steve and Kirillova;Anna and Seo;Kinya and Huang;Yong and Raja;Archana and Zhen;Jimmy and Ashley;Euan and Bustamante;Carlos and Rivas;Manuel and Ioannidis;Alex and Pinksy;Benjamin and Shoura;Massa and Hammond;Nathan and Watson;Nathaniel and Huang;ChunHong and Sahoo;Malaya and Wang;Hannah and Febbo;Phillip and Farh;Kyle and Schroth;Gary P. and DeSouza;Francis and Deboever;Christopher and Szalma;Sandor and Rubinacci;Simone and Delaneau;Olivier and McGuigan;Peter J. and Wasson;Christopher and Finn;Stephanie and Green;Jackie and Collins;Erin and King;Bernadette and Moore;Luke Stephen Prockter and Vizcaychipi;Marcela Paola and de Almeida Martins;Laura Gomes and Carungcong;Jaime and Hall;Kathryn and Mapfunde;Isheunesu and Campbell;Andy and Smuts;Sara and Duffield;Joseph and Smith;Oliver and Mallon;Lewis and Claire;Watkins and Nichol;Ailstair and Brickell;Kathy and Smyth;Michelle and Murphy;Lorna and Ward;Geraldine and Bremmer;Pamela and Page;Valerie Joan and Carmody;Siobhain and Semple;Malcolm G. and Solomon;Tom and Turtle;Lance C. W. and Hardwick;Hayley and Adeniji;Kayode and Agranoff;Daniel and Eziefula;Chi and Agwuh;Ken and Ail;Dhiraj and Aldera;Erin L. and Allen;Louise and Beranova;Eva and Crisp;Nikki and Deery;Joanne and Hazelton;Tracy and Knight;Alicia and Price;Carly and Tilbey;Sorrell and Turki;Salah and Turney;Sharon and Angus;Brian and Ashish;Abdul and Atkinson;Dougal and Bari;Shahedal and Barlow;Gavin and Barnass;Stella and Barrett;Nicholas and Douthwaite;Sam and Ostermann;Marlies and Shankar-Hari;Manu and Bassford;Christopher and Basude;Sneha and Baxter;David and Beadsworth;Michael and Welters;Ingeborg and Bernatoniene;Jolanta and Berridge;John and Best;Nicola and Bothma;Pieter and Tupper-Carey;Darell and Chadwick;David and Brittain-Long;Robin and Bulteel;Naomi and Murphy;Lee and Wrobel;Nicola and McCafferty;Sarah and Morrice;Kirstie and MacLean;Alan and Burden;Tom and Burtenshaw;Andrew and Caruth;Vikki and Chambler;Duncan and Chee;Nigel and Child;Jenny and Chukkambotla;Srikanth and Clark;Tom and Collini;Paul and Evans;Cariad and Mills;Gary H. and Ahmad;Norfaizan and Barker;Joann and Bauchmuller;Kris and Bird;Sarah and Cawthron;Kay and Harrington;Kate and Jackson;Yvonne and Kibutu;Faith and Lenagh;Becky and Masuko;Shamiso and Raithatha;Ajay and Wiles;Matthew and Willson;Jayne and Newell;Helen and Lye;Alison and Nwafor;Lorenza and Jarman;Claire and Rowland-Jones;Sarah and Foote;David and Cole;Joby and Thompson;Roger and Watson;James and Hesseldon;Lisa and Macharia;Irene and Chetam;Luke and Smith;Jacqui and Ford;Amber and Anderson;Samantha and Birchall;Kathryn and Housley;Kay and Walker;Sara and Milner;Leanne and Hanratty;Helena and Trower;Helen and Phillips;Patrick and Oxspring;Simon and Donne;Ben and Cosgrove;Catherine and Cupitt;Jason and Cutino-Moguel;Maria-Teresa and Dark;Paul and Dawson;Chris and Dervisevic;Samir and Drummond;Andrew and Ustianowski;Andrew and DuRand;Ingrid and Dushianthan;Ahilanadan and Dyer;Tristan and Fegan;Christopher and Finn;Adam and Fullerton;Duncan and Matovu;Elijah and Garg;Sanjeev and Garg;Atul and Gkrania-Klotsas;Effrossyni and Moore;Elinoor and Godden;Jo and Goldsmith;Arthur and Graham;Clive and Hardy;Elaine and Hartshorn;Stuart and Harvey;Daniel and Havalda;Peter and Workman;Andrew and Hawcutt;Daniel B. and Hobrok;Maria and Hodgson;Luke and Hormis;Anil and Jacobs;Michael and Jain;Susan and Jennings;Paul and Kaliappan;Agilan and Kasipandian;Vidya and Kegg;Stephen and Kelsey;Michael and Kerrison;Caroline and Kerslake;Ian and Koch;Oliver and Baruah;Rosie and Morris;Sheila and Ferguson;Susie and Shepherd;Amy and Koduri;Gouri and Koshy;George and Leiner;Tamas and Mortimore;Katherine and Laha;Shondipon and Laird;Steven and Larkin;Susan and Lillie;Patrick and Limb;James and Linnett;Vanessa and Little;Jeff and Lyttle;Mark and MacNaughton;Emily and Mankregod;Ravish and Masson;Huw and McCullough;Katherine and McEwen;Ruth and Wilson;Lawrence and Meda;Manjula and Minton;Jane and Ward;Karl and Mirfenderesky;Mariyam and Mohandas;Kavya and Mok;Quen and Moon;James and Capps;Nigel and Jose;Sanal and Morgan;Patrick and Morris;Craig and Moses;Samuel and Mpenge;Mbiye and Mulla;Rohinton and Murphy;Michael and Nagel;Megan and Nagarajan;Thapas and Nelson;Mark and O'Shea;Matthew K. and Green;Christoper A. and Otahal;Igor and Pais;Mark and Panchatsharam;Selva and Papakonstantinou;Danai and Bancroft;Hollie and Bellamy;Mary and Carmody;Margaret and Daglish;Jacqueline and Moore;Faye and Rhodes;Joanne and Sangombe;Mirriam and Kadiri;Salma and Scriven;James and Paraiso;Hassan and Patel;Brij and Pattison;Natalie and Pepperell;Justin and Phull;Mandeep and Pintus;Stefania and Pooni;Jagtur Singh and Post;Frank and Cavazza;Anna and Cockrell;Maeve and Corcoran;Eleanor and Depante;Maria and Finney;Clare and Jerome;Ellen and McPhail;Mark and Nayak;Monalisa and Noble;Harriet and O'Reilly;Kevin and Pappa;Evita and Saha;Rohit and Saha;Sian and Smith;John and Knighton;Abigail and Price;David and Prout;Rachel and Rae;Nikolas and Reschreiter;Henrik and Reynolds;Tim and Richardson;Neil and Roberts;Mark and Roberts;Devender and Rose;Alistair and Rousseau;Guy and Ryan;Brendan and Saluja;Taranprit and Shah;Aarti and Shanmuga;Prad and Sharma;Anil and Shawcross;Anna and Sizer;Jeremy and Bastion;Victoria and Clarke;Daphene and David;Beena and Kent;Harriet and Lorusso;Rachel and Lubimbi;Gamu and Murdoch;Sophie and Penacerrada;Melchizedek and Thomas;Alastair and Valentine;Jennifer and Vochin;Ana and Wulandari;Retno and Djeugam;Brice and Smith;Richard and Snelson;Catherine and Whitehouse;Tony and Spittle;Nick and Staines;Nikki and Visuvanathan;Shico and Stambach;Tom and Stewart;Richard and Subudhi;Pradeep and Szakmany;Tamas and Tatham;Kate and Thomas;Jo and Thompson;Chris and Tridente;Ascanio and Twagira;Mary and Vallotton;Nick and Vincent-Smith;Lisa and Vuylsteke;Alan and Waddy;Sam and Wake;Rachel and Walden;Andrew and Whittaker;Paul and Whittington;Ashley and Papineni;Padmasayee and Wijesinghe;Meme and Winchester;Stephen and 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and Houlden;Henry and Moncur;Eleanor and Tariq;Ambreen and Tucci;Arianna and Convery;Karen and Fottrell-Gould;Deirdre and Hudig;Lisa and Keshet-Price;Jocelyn and Randell;Georgina and Stammers;Katie and Abdelrazik;Marwa and Bakthavatsalam;Dhanalakshmi and Elhassan;Munzir and Ganesan;Arunkumar and Haldeos;Anne and Moreno-Cuesta;Jeronimo and Purohit;Dharam and Vincent;Rachel and Xavier;Kugan and Rohit;Kumar and Alasdair;Frater and Saleem;Malik and David;Carter and Jenkins;Samuel and Lamond;Zoe and Wall;Alanna and Reynolds;Jessica and Campbell;Helen and Thompsom;Maria and Dodds;Steve and Duffy;Stacey and Butcher;Deborah and O'Sullivan;Susie and Butterworth-Cowin;Nicola and Deacon;Bethan and Hibbert;Meg and Pothecary;Carla and Tetla;Dariusz and Woodford;Christopher and Durga;Latha and Kennard-Holden;Gareth and De Gordoa;Laura Ortiz-Ruiz and Peasgood;Emily and Phillips;Claire and Skinner;Denise and Gaylard;Jane and Mullan;Dee and Newman;Julie and Davies;Ellie and Roche;Lisa and Sathe;Sonia and Brimfield;Lutece and Daly;Zoe and Pogson;David and Rose;Steve and Collins;Amy and Khaliq;Waqas and Gude;Estefania Treus and Giles;Julian and Booth;Simon and Bell;Gillian and English;Katy and Katary;Amro and Wilcox;Louise and Campbell;Rachael and Clarke;Noreen and Whiteside;Jonathan and Mascarenhas;Mairi and Donaldson;Avril and Matheson;Joanna and Barrett;Fiona and O'Hara;Marianne and O'Keefe;Laura and Bradley;Clare and Collier;Dawn and Walker;Rachel and Maynard;Victoria and Patel;Tahera and Smith;Matthew and Kazi;Aayesha and Hartley;Janice and Dykes;Joseph and Hijazi;Muhammad and Keith;Sarah and Khan;Meherunnisa and Ryan-Smith;Janet and Springle;Philippa and Thomas;Jacqueline and Truman;Nick and Saad;Samuel and Coleman;Dabheoc and Fine;Christopher and Matt;Roseanna and Gay;Bethan and Dalziel;Jack and Ali;Syamlan and Goodchild;Drew and Harling;Rhiannan and Bhatterjee;Ravi and Goddard;Wendy and Davison;Chloe and Duberly;Stephen and Hargreaves;Jeanette and Bolton;Rachel and 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and Gummadi;Mahitha and Liyanage;Kamal and Salmi;Sara and Sloane;Geraldine and Varghese;Mathew and Zborowski;Anelise C. and Patel;V;Brijesh and Bean;Sarah and Burt;Karen and Spivey;Michael and Eastgate-Jackson;Christine and Filipe;Helder and Martin;Daniel and Maharajh;Amitaa and Garcia;Sara Mingo and De Neef;Mark and Lynch;Ceri and Howe;Gwenllian Sera and Singh;Jayaprakash and Turner;Keri and Ellis;Hannah and Stroud;Natalie and Cherian;Shiney and Cutler;Sean and Heron;Anne Emma and Roynon-Reed;Anna and Williams;Gemma and Richards;Owen and Cheema;Yusuf and Bevan;Emily and Martin;Jane and Trodd;Dawn and Watson;Geoff and Brown;Caroline Wrey and Bunni;Lara and Jennings;Claire and Latif;Monica and Marshall;Rebecca and Subramanian;Gayathri and Bandla;Nageswar and Gellamucho;Minnie and Davies;Michelle and Thompson;Christopher and Donnison;Phil and Trim;Fiona and Eapen;Beena and Ahmed;Cecilia and Baines;Balvinder and Clamp;Sarah and Colley;Julie and Haq;Risna and Hayes;Anne and Hulme;Jonathan and Hussain;Samia and Joseph;Sibet and Kumar;Rita and Maqsood;Zahira and Purewal;Manjit and Chandler;Ben and Elliott;Kerry and Mallinson;Janine and Turnbull;Alison and Dent;Kathy and Horsley;Elizabeth and Akhtar;Muhmmad Nauman and Pearson;Sandra and Potoczna;Dorota and Spencer;Sue and Blakemore;Hayley and Borislavova;Borislava and Faulkner;Beverley and Gendall;Emma and Goff;Elizabeth and Hayes;Kati and Thomas;Matt and Worner;Ruth and Smith;Kerry and Stephens;Deanna and Delgado;Carlos Castro and Dawson;Deborah and Ding;Lijun and Durrant;Georgia and Ezeobu;Obiageri and Farnell-Ward;Sarah and Harrison;Abiola and Kanu;Rebecca and Leaver;Susannah and Maccacari;Elena and Manna;Soumendu and Saluzzio;Romina Pepermans and Queiroz;Joana and Samakomva;Tinashe and Sicat;Christine and Texeira;Joana and Da Gloria;Edna Fernandes and Lisboa;Ana and Rawlins;John and Mathew;Jisha and Kinch;Ashley and Hurt;William James and Shah;Nirav and Clark;Victoria and Thanasi;Maria and Yun;Nikki and Patel;Kamal and 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L. and McHugh;Tara and Meghari;Hamza and O'Neill;Lauran and Peters;Mark J. and Ray;Samiran and Tomas;Ana Luisa and Gorman;Claire and Gupta;Abhinav and Timlick;Elizabeth and Brady;Rebecca and Bonner;Stephen and Hugill;Keith and Jones;Jessica and Liggett;Steven and Bashyal;Archana and Davidson;Neil and Hutton;Paula and McKechnie;Stuart and Wilson;Jean and Flint;Neil and Rekha;Patel and Hales;Dawn and Cruz;Carina and Gopal;Shameer and Harris;Nichola and Lake;Victoria and Metherell;Stella and Radford;Elizabeth and Clement;Ian and Patel;Bijal and Gulati;A. and Hays;Carole and Webster;K. and Hudson;Anne and Webster;Andrea and Stephenson;Elaine and McCormack;Louise and Slater;Victoria and Nixon;Rachel and Hanson;Helen and Fearby;Maggie and Kelly;Sinead and Bridgett;Victoria and Robinson;Philip and Almaden-Boyle;Christine and Austin;Pauline and Cabrelli;Louise and Cole;Stephen and Casey;Matt and Chapman;Susan and Whyte;Clare and Brayne;Adam and Fisher;Emma and Hunt;Jane and Jackson;Peter and Kaye;Duncan and Love;Nicholas and Parkin;Juliet and Tuckey;Victoria and van Koutrik;Lynne and Carter;Sasha and Andrew;Benedict and Findlay;Louise and Adams;Katie and Bruce;Michelle and Connolly;Karen and Duncan;Tracy and T-Michael;Helen and Lindergard;Gabriella and Hey;Samuel and Fox;Claire and Alfonso;Jordan and Durrans;Laura Jayne and Guerin;Jacinta and Hruska;Martin and Eltayeb;Ayaa and Lamb;Thomas and Hodgkiss;Tracey and Cooper;Lisa and Rothwell;Joanne and Dennis;Catherine and McGregor;Alastair and Srikaran;Sinduya and Sukha;Anisha and Davies;Kim and O'Brien;Linda and Omar;Zohra and Perkins;Emma and Lewis;Tracy and Sutherland;Isobel and Brooke;Hollie and Buckley;Sarah and Suarez;Jose Cebrian and Charlesworth;Ruth and Hansson;Karen and Norris;John and Poole;Alice and Rose;Alastair and Sandhu;Rajdeep and Sloan;Brendan and Smithson;Elizabeth and Thirumaran;Muthu and Wagstaff;Veronica and Metcalfe;Alexandra and Camsooksai;Julie and Humphrey;Charlotte and Jenkins;Sarah and 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Eunice and Flaherty;Lisa and Maziere;Nicole and Cass;Emily and Carracedo;Alejandra Doce and Carlucci;Nicola and Holmes;Anthony and Massey;Hannah and Brennan;Benjamin and Lake;Annette and Lefteri;Daniella and McLauchlan;John and Taggart;Aislynn and Coutts;Audrey and Donnelly;Lorna and Fawkes;Angie and Gilchrist;Tammy and Hafezi;Katarzyna and Macgillivray;Louise and Schon;Katherine and Furlong;Anita and Biggs;Heather and Rakitko;Alexander and Ilinsky;Valery and Yermakovich;Danat and Popov;Iaroslav and Chernitsov;Alexander and Kovalenko;Elena and Krasnenko;Anna and Plotnikov;Nikolay and Stetsenko;Ivan and Kim;Anna and Cirulli;Elizabeth T. and Barrett;Kelly M. Schiabor and Bolze;Alexandre and White;Simon and Washington;Nicole L. and Lu;James T. and Riffle;Stephen and Tanudjaja;Francisco and Wang;Xueqing and Iii;Jimmy M. Ramirez and Leonetti;Nicole and Sandoval;Efren and Neveux;Iva and Grzymski;Joseph J. and Dabe;Shaun and Minano;Juan Ignacio Esteban and Pazos;Manuel de la Mata and Cerrato;Luciano and Aguirre;Luis A. and Lopez-Collazo;Eduardo and Lozano-Rodriguez;Roberto and Avendano-Ortiz;Jose and Arcos;Veronica Terron and Montalban-Hernandez;Karla Marina and Quiroga;Jaime Valentin and Pascual-Iglesias;Alejandro and Maroun-Eid;Charbel and Martin-Quiros;Alejandro and Namkoong;Ho and Fukunaga;Koichi and Ishii;Makoto and Kabata;Hiroki and Masaki;Katsunori and Kamata;Hirofumi and Ikemura;Shinnosuke and Chubachi;Shotaro and Okamori;Satoshi and Terai;Hideki and Tanaka;Hiromu and Morita;Atsuho and Lee;Ho and Asakura;Takanori and Edahiro;Ryuya and Sonehara;Kyuto and Shirai;Yuya and Suzuki;Ken and Kumanogoh;Atsushi and Imoto;Seiya and Katayama;Kazuhiko and Kitagawa;Yuko and Sato;Toshiro and Hasegawa;Naoki and Takeda;Yoshito and Hirata;Haruhiko and Shiroyama;Takayuki and Maeda;Yuichi and Nii;Takuro and Noda;Yoshimi and Niitsu;Takayuki and Adachi;Yuichi and Enomoto;Takatoshi and Amiya;Saori and Hara;Reina and Kimura;Akinori and Ai;Masumi and Tokunaga;Katsushi and Omae;Yosuke and Kanai;Takanori and Nanki;Kosaku and Mikami;Yohei and Miyano;Satoru and Takahashi;Kunihiko and Anzai;Tatsuhiko and Hasegawa;Takanori and Ito;Satoshi and Ogawa;Seishi and Sasaki;Junichi and Morisaki;Hiroshi and Uwamino;Yoshifumi and Tomono;Kazunori and Kato;Kazuto and Matsuda;Fumihiko and Takahashi;Meiko and Hizawa;Nobuyuki and Miyawaki;Satoru and Koike;Ryuji and Endo;Akifumi and Uchimura;Yuji and Miyazaki;Yasunari and Honda;Takayuki and Tateishi;Tomoya and Tohda;Shuji and Ichimura;Naoya and Sonobe;Kazunari and Sassa;Chihiro and Nakajima;Jun and Nannya;Yasuhito and Takahashi;Kazuhisa and Harada;Norihiro and Takagi;Haruhi and Nakamura;Ai and Hiki;Makoto and Tagaya;Etsuko and Arimura;Ken and Kawana;Masatoshi and Ishiguro;Takashi and Takayanagi;Noboru and Isono;Taisuke and Takaku;Yotaro and Takano;Kenji and Anan;Ryusuke and Nakajima;Yukiko and Nakano;Yasushi and Nishio;Kazumi and Ueda;Soichiro and Hayashi;Reina and Tateno;Hiroki and Hase;Isano and Yoshida;Shuichi and Suzuki;Shoji and Mitamura;Keiko and Saito;Fumitake and Ueda;Tetsuya and Azuma;Masanori and Nagasaki;Tadao and Hasegawa;Yoshinori and Okamoto;Masaki and Yasui;Yoshinori and Mutoh;Yoshikazu and Yoshiyama;Takashi and Shoko;Tomohisa and Kojima;Mitsuaki and Adachi;Tomohiro and Ishikawa;Motonao and Takahashi;Kenichiro and Watanabe;Kazuyoshi and Manabe;Tadashi and Ito;Fumimaro and Fukui;Takahiro and Funatsu;Yohei and Koh;Hidefumi and Hirai;Yoshihiro and Kawashima;Hidetoshi and Narita;Atsuya and Niwa;Kazuki and Sekikawa;Yoshiyuki and Saito;Fukuki and Yoshiya;Kazuhisa and Yoshihara;Tomoyuki and Suzuki;Yusuke and Nakayama;Sohei and Masuzawa;Keita and Nishi;Koichi and Nishitsuji;Masaru and Tani;Maiko and Inoue;Takashi and Hirano;Toshiyuki and Kobayashi;Keigo and Miyazawa;Naoki and Kimura;Yasuhiro and Sado;Reiko and Ogura;Takashi and 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and Wakahara;Keiko and Ando;Akira and Masuda;Makoto and Wakabayashi;Aya and Watanabe;Hiroki and Sageshima;Hisako and Nakada;Taka-Aki and Abe;Ryuzo and Shimada;Tadanaga and Kawamura;Kodai and Ichikado;Kazuya and Nishiyama;Kenta and Yamasaki;Masaki and Hashimoto;Satoru and Kusaka;Yu and Ohba;Takehiko and Isogai;Susumu and Takada;Minoru and Kanda;Hidenori and Komase;Yuko and Sano;Fumiaki and Asano;Koichiro and Oguma;Tsuyoshi and Harada;Masahiro and Takahashi;Takeshi and Shibusawa;Takayuki and Abe;Shinji and Kono;Yuta and Togashi;Yuki and Izumo;Takehiro and Inomata;Minoru and Awano;Nobuyasu and Ogawa;Shinichi and Ogata;Tomouki and Ishihara;Shoichiro and Kanehiro;Arihiko and Ozaki;Shinji and Fuchimoto;Yasuko and Kitagawa;Yuichiro and Yoshida;Shozo and Ogura;Shinji and Nishiyama;Kei and Yoshida;Kousuke and Beppu;Satoru and Fukuyama;Satoru and Eriguchi;Yoshihiro and Yonekawa;Akiko and Inoue;Yoshiaki and Yamagata;Kunihiro and Chiba;Shigeru and Narumoto;Osamu and Nagai;Hideaki and Ooshima;Nobuharu and Motegi;Mitsuru and Sagara;Hironori and Tanaka;Akihiko and Ohta;Shin and Shibata;Yoko and Tanino;Yoshinori and Sato;Yuki and Yamada;Yuichiro and Hashino;Takuya and Shinoki;Masato and Iwagoe;Hajime and Imamura;Tomonori and Umeda;Akira and Shimada;Hisato and Endo;Mayu and Hayashi;Shinichi and Takahashi;Mai and Nakano;Shigefumi and Yatomi;Masakiyo and Maeno;Toshitaka and Ishii;Tomoo and Utsugi;Mitsuyoshi and Ono;Akihiro and Kanaoka;Kensuke and Ihara;Shoichi and Komuta;Kiyoshi and Boezen;Marike and Vonk;Judith M. and Ori;Anil P. S. and Obeidat;Ma'en and Cordero;Ana I. Hernandez and Sin;Don D. and Bosse;Yohan and Joubert;Philippe and Hao;Ke and Sebra;Robert P. and Jordan;Daniel M. and Gettler;Kyle and Chaudhary;Kumardeep and Salib;Irene and Zyndorf;Marissa and Schadt;Eric E. and Cho;Judy H. and Itan;Yuval and Do;Ron and Nickle;David and Timens;Wim and van den Berge;Maarten and Feng;Yen-Chen Anne and Meigs;James B. and Weiss;Scott T. and Karlson;Elizabeth W. and Woolley;Ann E. and Smoller;Jordan W. and Murphy;Shawn N. and Ascolillo;Steven and Thompson;Ryan C. and Beckmann;Noam D. and Nadkarni;Girish N. and Boutros;Paul and Charney;Alexander W. and Hoggart;Clive and Choi;Sam and O'Reilly;Paul and Huckins;Laura M. and Preuss;Michael and Loos;Ruth J. F. and Belbin;Gillian M. and Abul-Husn;Noura S. and Kenny;Eimear E. and Geschwind;Daniel H. and Ferreira;Manuel A. R. and Abecasis;Goncalo R. and Cantor;Michael N. and Kosmicki;Jack A. and Horowitz;Julie E. and Baras;Aris and Yadav;Ashish and Leader;Joseph B. and Gass;Matthew C. and Justice;Anne E. and Chittoor;Geetha and Josyula;Navya Shilpa and Carey;Dave J. and Mirshahi;Tooraj and Verma;Anurag and Ritchie;Marylyn D. and Rader;Daniel and Verma;Shefali S. and Lucas;Anastasia and Bradford;Yuki and Li;Binglan and Brusco;Alfredo and Ferrero;Giovanni Battista and Butte;Manish J. and Scala;Marcello and Riva;Antonella and Rahier;Jean-Francois and Giorgio;Elisa and Carli;Diana and Afifi;Nahla and Klovins;Janis and Rovite;Vita and Rescenko;Raimonds and Peculis;Raitis and Ustinova;Monta and Zeberg;Hugo and Frithiof;Robert and Hultstrom;Michael and Lipcsey;Miklos and Johnson;Ruth and Freimer;Nelson and Ding;Yi and Chiu;Alec and Chang;Timothy S. and Wilson;Daniel J. and Earle;Sarah G. and Lin;Shang-Kuan and Arning;Nicolas and Armstrong;Jacob and Rudkin;Justine K. and Crook;Derrick W. and Wyllie;David H. and O'Connell;Anne Marie and Callier;Shawneequa and Soranzo;Nicole and Zhao;Jing Hua and Danesh;John and Di Angelantonio;Emanuele and Butterworth;Adam S. and Sun;V;Yan and Huffman;Jennifer E. and O'Donnell;Christopher J. and Peloso;Gina and Cho;Kelly and Gaziano;J. Michael and Ho;Yuk-Lam and Tsao;Phil and Mian;Michael and Scaggiante;Federica and Chang;Xiao and Glessner;Joseph R. and Hakonarson;Hakon and Vincenti;Antonella and Ferri;Grassi, Claudio;Davide and Pessina;Gloria and Di Pietro;Massimo and Luchi;Sauro and Barbieri;Chiara and Acquilini;Donatella and Andreucci;Elena and Poscente;Monica and Petrocelli;Paola and Tiseo;Giusy and Falcone;Marco and Segala;Francesco Vladimiro and Baroni;Silvia and Garcia-Fernandez;Alba-Estela and Blanco-Grau;Albert and Caballero-Garralda;Andrea and Cea;Cristina and Guerrero;Juan M. and Angelini;Claudio and Kurihara;Hayato and Ciccarelli;Michele and Bocciolone;Monica and Preatoni;Paoletta and Omodei;Paolo and Muniz-Diaz;Eduardo and Sandoval;Elena and Aziz;Fatima and Ferrusquia-Acosta;Jose and Moreira;Leticia and Cardamone;Giulia and Foti;Giuseppe and Matullo;Giuseppe and Aneli;Serena and Damas;Jan Kristian and Risnes;Kari and Bettini;Laura Rachele and Martin;Javier and Acosta-Herrera;Marialbert and Erdmann;Jeanette and Bergan;Jonas and Biondi;Andrea and D'Angio;Mariella and Solligard;Erik and Gustad;Lise Tuset and Schaefer;Marco and Peter;Wolfgang and Valsecchi;Maria G. and Cazzaniga;Marina and Faverio;Paola and Bonfanti;Paolo and Dopazo;Ximo and COVID-19 Host Genetics Initiative
2021
Abstract
The genetic make-up of an individual contributes to the susceptibility
and response to viral infection. Although environmental, clinical and
social factors have a role in the chance of exposure to SARS-CoV-2 and
the severity of COVID-19(1,2), host genetics may also be important.
Identifying host-specific genetic factors may reveal biological
mechanisms of therapeutic relevance and clarify causal relationships of
modifiable environmental risk factors for SARS-CoV-2 infection and
outcomes. We formed a global network of researchers to investigate the
role of human genetics in SARS-CoV-2 infection and COVID-19 severity.
Here we describe the results of three genome-wide association
meta-analyses that consist of up to 49,562 patients with COVID-19 from
46 studies across 19 countries. We report 13 genome-wide significant
loci that are associated with SARS-CoV-2 infection or severe
manifestations of COVID-19. Several of these loci correspond to
previously documented associations to lung or autoimmune and
inflammatory diseases(3-7). They also represent potentially actionable
mechanisms in response to infection. Mendelian randomization analyses
support a causal role for smoking and body-mass index for severe
COVID-19 although not for type II diabetes. The identification of novel
host genetic factors associated with COVID-19 was made possible by the
community of human genetics researchers coming together to prioritize
the sharing of data, results, resources and analytical frameworks. This
working model of international collaboration underscores what is
possible for future genetic discoveries in emerging pandemics, or indeed
for any complex human disease.
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C., And Striano, U., And Coviello, P., And Zara, D. A., And Salpietro, F., Iacomino, V., And Scudieri, M., And Bocciardi, P., And Minetti, R., And Vari, C., Stella And Madia, M., And Marouli, F., And Kanoni, E., And Moutsianas, S., And Karim, L., Anisul And Ghoussaini, M., And Schwartzentruber, M., And Dunham, J., And Savage, I., And Posthuma, J., And Tissink, D., And Uffelmann, E., And Butler-Laporte, E., And Richards, G., Brent And Nakanishi, J., And Morrison, T., And Forgetta, D. R., And Ghosh, V., And Laurent, B., And Henry, L., And Abdullah, D., And Adeleye, T., And Mamlouk, O., And Kimchi, N., And Afrasiabi, N., And Rezk, Z., And Vulesevic, N., And Bouab, B., And Guzman, M., And Petitjean, C., And Tselios, L., And Xue, C., And Afilalo, X., And Adra, J., And Kim, D., And Okada, H., And Byun, Y., And Han, J., And Uddin, Y., Jashim And Smith, M., Davey And Willer, G., And Buxbaum, C. J., And Sloofman, J. D., And Collins, L. G., And Levy, B. L., And Underwood, T., And Britvan, S. 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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
