Envelope protein of coronaviruses is a structural protein existing in both monomeric and homopentameric form. It has been related to a multitude of roles including virus infection, replication, dissemination and immune response stimulation. In the present study, we employed an immunoinformatic approach to investigate the major immunogenic domains of the SARS-CoV-2 envelope protein and map them among the homologue proteins of coronaviruses with tropism for animal species that are closely inter-related with the human beings population all over the world. Also, when not available, we predicted the envelope protein structural folding and mapped SARS-CoV-2 epitopes. Envelope sequences alignment provides evidence of high sequence homology for some of the investigated virus specimens; while the structural mapping of epitopes resulted in the interesting maintenance of the structural folding and epitope sequence localization also in the envelope proteins scoring a lower alignment score. In line with the One-Health approach, our evidences provide a molecular structural rationale for a potential role of taxonomically related coronaviruses in conferring protection from SARSCoV- 2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies.

Tilocca, B., Soggiu, A., Sanguinetti, M., Babini, G., De Maio, F., Britti, D., Zecconi, A., Bonizzi, L., Urbani, A., Roncada, P., Original Immunoinformatic analysis of the SARS-CoV-2 envelope protein asa strategy to assess cross -protection against COVID-19, <<MICROBES AND INFECTION>>, 2020; 22 (4-5): 182-187. [doi:10.1016/j.micinf.2020.05.013] [https://hdl.handle.net/10807/232537]

Original Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross -protection against COVID-19

Sanguinetti, Maurizio;De Maio, Flavio;Urbani, Andrea
;
Roncada, Paola
2020

Abstract

Envelope protein of coronaviruses is a structural protein existing in both monomeric and homopentameric form. It has been related to a multitude of roles including virus infection, replication, dissemination and immune response stimulation. In the present study, we employed an immunoinformatic approach to investigate the major immunogenic domains of the SARS-CoV-2 envelope protein and map them among the homologue proteins of coronaviruses with tropism for animal species that are closely inter-related with the human beings population all over the world. Also, when not available, we predicted the envelope protein structural folding and mapped SARS-CoV-2 epitopes. Envelope sequences alignment provides evidence of high sequence homology for some of the investigated virus specimens; while the structural mapping of epitopes resulted in the interesting maintenance of the structural folding and epitope sequence localization also in the envelope proteins scoring a lower alignment score. In line with the One-Health approach, our evidences provide a molecular structural rationale for a potential role of taxonomically related coronaviruses in conferring protection from SARSCoV- 2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies.
2020
Inglese
Tilocca, B., Soggiu, A., Sanguinetti, M., Babini, G., De Maio, F., Britti, D., Zecconi, A., Bonizzi, L., Urbani, A., Roncada, P., Original Immunoinformatic analysis of the SARS-CoV-2 envelope protein asa strategy to assess cross -protection against COVID-19, <<MICROBES AND INFECTION>>, 2020; 22 (4-5): 182-187. [doi:10.1016/j.micinf.2020.05.013] [https://hdl.handle.net/10807/232537]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/232537
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 34
social impact