The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.
Berisio, R., Delogu, G., PGRS domain structures: Doomed to sail the mycomembrane, <<PLOS PATHOGENS>>, 2022; 18 (9): e1010760-N/A. [doi:10.1371/journal.ppat.1010760] [https://hdl.handle.net/10807/232289]
PGRS domain structures: Doomed to sail the mycomembrane
Delogu, Giovanni
2022
Abstract
The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.
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