Background: Peri-implantitis is a pathological condition characterized by an inflammatory process involving soft and hard tissues surrounding dental implants. The management of peri-implant disease has several protocols, among which is the chemical method HYBENX(R). The aim of this study is to demonstrate the efficacy of HYBENX(R) in the treatment of peri-implantitis and to compare HYBENX(R) with other chemical agents used in the surgical treatment of peri-implantitis. Methods: The present study included a population of ten subjects with severe peri-implantitis. The procedure used in the study involves the application of HYBENX(R) after open-flap debridement. Each patient has been followed for 12 months after a single application of the decontaminant agent. Clinical and radiographical parameters were recorded at baseline, 3 months, and 12 months after treatment completion. Results: At baseline, a mean pocket probing depth (PPD) of 7.3 +/- 0.5 mm and a mean clinical attachment level (CAL) of 8.8 +/- 0.8 mm was recorded. An average residual PPD of 4.2 +/- 0.5 mm and a mean CAL of 5.2 +/- 0.8 mm were observed after 1 year. Additionally, the average of bone gain was about 3.4 mm, with a mean marginal bone level (MBL) change from 5.8 mm (baseline) to 2.4 mm (12 months). In total, 90% of the treated implants reached the success rate after the 1-year follow-up. Only in one case out of ten treated implants was resolution of the disease not achieved. Conclusion: Clinical improvements highlight that the procedure of open-flap debridement (OFD) + HYBENX(R) may be considered an effective technique in the treatment of peri-implantitis. From the results obtained, it can be concluded that the use of HYBENX(R) in the surgical treatment of peri-implantitis is promising. Overall, this protocol demands further studies to better understand the role and potential benefits of HYBENX(R) in the treatment of peri-implantitis.
Lopez, M. A., Passarelli, P. C., Godino, E., Lombardo, N., Altamura, F. R., Speranza, A., Lopez, A., Papi, P., Pompa, G., D'Addona, A., The Treatment of Peri-Implant Diseases: A New Approach Using HYBENX® as a Decontaminant for Implant Surface and Oral Tissues, <<ANTIBIOTICS>>, 2021; 10 (5): 512-N/A. [doi:10.3390/antibiotics10050512] [https://hdl.handle.net/10807/232208]
The Treatment of Peri-Implant Diseases: A New Approach Using HYBENX® as a Decontaminant for Implant Surface and Oral Tissues
Lopez, Michele Antonio;Passarelli, Pier Carmine;Papi, Piero;D'Addona, Antonio
2021
Abstract
Background: Peri-implantitis is a pathological condition characterized by an inflammatory process involving soft and hard tissues surrounding dental implants. The management of peri-implant disease has several protocols, among which is the chemical method HYBENX(R). The aim of this study is to demonstrate the efficacy of HYBENX(R) in the treatment of peri-implantitis and to compare HYBENX(R) with other chemical agents used in the surgical treatment of peri-implantitis. Methods: The present study included a population of ten subjects with severe peri-implantitis. The procedure used in the study involves the application of HYBENX(R) after open-flap debridement. Each patient has been followed for 12 months after a single application of the decontaminant agent. Clinical and radiographical parameters were recorded at baseline, 3 months, and 12 months after treatment completion. Results: At baseline, a mean pocket probing depth (PPD) of 7.3 +/- 0.5 mm and a mean clinical attachment level (CAL) of 8.8 +/- 0.8 mm was recorded. An average residual PPD of 4.2 +/- 0.5 mm and a mean CAL of 5.2 +/- 0.8 mm were observed after 1 year. Additionally, the average of bone gain was about 3.4 mm, with a mean marginal bone level (MBL) change from 5.8 mm (baseline) to 2.4 mm (12 months). In total, 90% of the treated implants reached the success rate after the 1-year follow-up. Only in one case out of ten treated implants was resolution of the disease not achieved. Conclusion: Clinical improvements highlight that the procedure of open-flap debridement (OFD) + HYBENX(R) may be considered an effective technique in the treatment of peri-implantitis. From the results obtained, it can be concluded that the use of HYBENX(R) in the surgical treatment of peri-implantitis is promising. Overall, this protocol demands further studies to better understand the role and potential benefits of HYBENX(R) in the treatment of peri-implantitis.
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