Background and aims: In cirrhosis, decreased portal flow velocity, thrombophilia factors, and portal hyper-tension are considered risk factors for portal vein thrombosis (PVT). In cirrhosis, the transformation of the stellate cells causes a progressive decrease of ADAMTS-13, while VWF multimers secretion by endothelial cells is strongly enhanced. This imbalance leads to an accumulation of ultra-large VWF multimers that in sinusoidal circulation could favor PVT both in intra-and extra-hepatic branches, mostly in decompensated cirrhosis. This prospective study was aimed at identifying possible clinical, biochemical, and hemostatic factors predictive for non-tumoral PVT in a cohort of patients with compensated cirrhosis.Methods: Seventynine compensated cirrhosis patients were prospectively followed for 48 months, receiv-ing a periodic Doppler-ultrasound liver examination associated with an extensive evaluation of clinical, biochemical, and hemostatic profile.Results: Five patients developed PVT (cumulative prevalence = 6.3%), occurring 4-36 months after enroll-ment. In logistic regression analysis, the ADAMTS-13/VWF:GpIbR ratio < 0.4 was the only independent variable significantly associated with PVT (OR 14.6, 95% C.I.:1.36-157.2, p = 0.027). A Cox-regression -analysis confirmed this finding (HR = 7.7, p = 0.027).Conclusions: The ADAMTS-13/VWF ratio < 0.4 measured in compensated cirrhosis could be a reliable predictive biomarker for PVT development, paving the way to novel therapeutic strategies to prevent and treat PVT in this clinical setting.(c) 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Sacco, M., Tardugno, M., Lancellotti, S., Ferretti, A., Ponziani, F. R., Riccardi, L., Zocco, M. A., De Magistris, A., Santopaolo, F., Pompili, M., De Cristofaro, R., ADAMTS-13/von Willebrand factor ratio: A prognostic biomarker for portal vein thrombosis in compensated cirrhosis. A prospective observational study, <<DIGESTIVE AND LIVER DISEASE>>, 2022; 54 (12): 1672-1680. [doi:10.1016/j.dld.2022.06.004] [https://hdl.handle.net/10807/231850]

ADAMTS-13/von Willebrand factor ratio: A prognostic biomarker for portal vein thrombosis in compensated cirrhosis. A prospective observational study

Sacco, Monica;Tardugno, Maira;Ponziani, Francesca Romana;Riccardi, Laura;Zocco, Maria Assunta;Santopaolo, Francesco;Pompili, Maurizio;De Cristofaro, Raimondo
2022

Abstract

Background and aims: In cirrhosis, decreased portal flow velocity, thrombophilia factors, and portal hyper-tension are considered risk factors for portal vein thrombosis (PVT). In cirrhosis, the transformation of the stellate cells causes a progressive decrease of ADAMTS-13, while VWF multimers secretion by endothelial cells is strongly enhanced. This imbalance leads to an accumulation of ultra-large VWF multimers that in sinusoidal circulation could favor PVT both in intra-and extra-hepatic branches, mostly in decompensated cirrhosis. This prospective study was aimed at identifying possible clinical, biochemical, and hemostatic factors predictive for non-tumoral PVT in a cohort of patients with compensated cirrhosis.Methods: Seventynine compensated cirrhosis patients were prospectively followed for 48 months, receiv-ing a periodic Doppler-ultrasound liver examination associated with an extensive evaluation of clinical, biochemical, and hemostatic profile.Results: Five patients developed PVT (cumulative prevalence = 6.3%), occurring 4-36 months after enroll-ment. In logistic regression analysis, the ADAMTS-13/VWF:GpIbR ratio < 0.4 was the only independent variable significantly associated with PVT (OR 14.6, 95% C.I.:1.36-157.2, p = 0.027). A Cox-regression -analysis confirmed this finding (HR = 7.7, p = 0.027).Conclusions: The ADAMTS-13/VWF ratio < 0.4 measured in compensated cirrhosis could be a reliable predictive biomarker for PVT development, paving the way to novel therapeutic strategies to prevent and treat PVT in this clinical setting.(c) 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
2022
Inglese
Sacco, M., Tardugno, M., Lancellotti, S., Ferretti, A., Ponziani, F. R., Riccardi, L., Zocco, M. A., De Magistris, A., Santopaolo, F., Pompili, M., De Cristofaro, R., ADAMTS-13/von Willebrand factor ratio: A prognostic biomarker for portal vein thrombosis in compensated cirrhosis. A prospective observational study, <<DIGESTIVE AND LIVER DISEASE>>, 2022; 54 (12): 1672-1680. [doi:10.1016/j.dld.2022.06.004] [https://hdl.handle.net/10807/231850]
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