Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led to improved treatment and quality of life. The introduction of targeted-biologic and -synthetic disease modifying antirheumatic drugs (DMARDs) has also transformed clinical outcomes. Despite this, RA remains a life-long disease without a cure. Unmet needs include partial response and non-response to treatment in many patients, failure to achieve immune homeostasis or drug free remission, and inability to repair damaged tissues. RA is now recognized as the end of a multi-year prodromal phase in which systemic immune dysregulation, likely beginning in mucosal surfaces, is followed by a symptomatic clinical phase. Inflammation and immune reactivity are primarily localized to the synovium leading to pain and articular damage, but is also associated with a broader series of comorbidities. Here, we review recently described immunologic mechanisms that drive breach of tolerance, chronic synovitis, and remission.

Alivernini, S., Firestein, G. S., Mcinnes, I. B., The pathogenesis of rheumatoid arthritis, <<IMMUNITY>>, N/A; 55 (12): 2255-2270. [doi:10.1016/j.immuni.2022.11.009] [https://hdl.handle.net/10807/231254]

The pathogenesis of rheumatoid arthritis

Alivernini, Stefano
Primo
Membro del Collaboration Group
;
2022

Abstract

Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led to improved treatment and quality of life. The introduction of targeted-biologic and -synthetic disease modifying antirheumatic drugs (DMARDs) has also transformed clinical outcomes. Despite this, RA remains a life-long disease without a cure. Unmet needs include partial response and non-response to treatment in many patients, failure to achieve immune homeostasis or drug free remission, and inability to repair damaged tissues. RA is now recognized as the end of a multi-year prodromal phase in which systemic immune dysregulation, likely beginning in mucosal surfaces, is followed by a symptomatic clinical phase. Inflammation and immune reactivity are primarily localized to the synovium leading to pain and articular damage, but is also associated with a broader series of comorbidities. Here, we review recently described immunologic mechanisms that drive breach of tolerance, chronic synovitis, and remission.
2022
Inglese
Alivernini, S., Firestein, G. S., Mcinnes, I. B., The pathogenesis of rheumatoid arthritis, <<IMMUNITY>>, N/A; 55 (12): 2255-2270. [doi:10.1016/j.immuni.2022.11.009] [https://hdl.handle.net/10807/231254]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/231254
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