BACKGROUND:This study assessed the effectiveness of the use of ketorolac tromethamine to reduce retinopathy of prematurity (ROP) incidence and its progression to more severe forms. METHODS:Forty-seven preterm newborn infants with a birth weight (BW) of 1,000 grams or less and/or a gestational age (GA) of 29 weeks or less were enrolled in the study when avascular retina zone I or ROP any stage were diagnosed at screening. Studied infants were randomized to receive ketorolac tromethamine ophthalmic solution in one eye and a drop of placebo in the other eye, until ROP requiring treatment or full retinal vascularization was diagnosed. RESULTS:Only 2 newborn infants did not develop ROP. Among 45 newborn infants who developed ROP, 6 showed different ROP staging between the two eyes, 4 of which had a better outcome in the eye receiving ketorolac tromethamine. The differences between ROP stagings were not significant even when analyzed by GA and BW subgroups. No significant treatment-related side effects occurred. CONCLUSION:This report suggests that ketorolac tromethamine ophthalmic solution cannot reduce the risk of developing severe ROP in preterm infants.

Giannantonio, C., Papacci, P., Purcaro, V., Cota, F., Tesfagabir, G., Molle, F., Lepore, D., Baldascino, A., Romagnoli, C., Effectiveness of Ketorolac Tromethamine in Prevention of Severe Retinopathy of Prematurity., <<JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS>>, 2010; (Settembre): 1-5 [http://hdl.handle.net/10807/23113]

Effectiveness of Ketorolac Tromethamine in Prevention of Severe Retinopathy of Prematurity.

Giannantonio, Carmen;Papacci, Patrizia;Purcaro, Velia;Cota, Francesco;Molle, Fernando;Lepore, Domenico;Baldascino, Antonio;Romagnoli, Costantino
2010

Abstract

BACKGROUND:This study assessed the effectiveness of the use of ketorolac tromethamine to reduce retinopathy of prematurity (ROP) incidence and its progression to more severe forms. METHODS:Forty-seven preterm newborn infants with a birth weight (BW) of 1,000 grams or less and/or a gestational age (GA) of 29 weeks or less were enrolled in the study when avascular retina zone I or ROP any stage were diagnosed at screening. Studied infants were randomized to receive ketorolac tromethamine ophthalmic solution in one eye and a drop of placebo in the other eye, until ROP requiring treatment or full retinal vascularization was diagnosed. RESULTS:Only 2 newborn infants did not develop ROP. Among 45 newborn infants who developed ROP, 6 showed different ROP staging between the two eyes, 4 of which had a better outcome in the eye receiving ketorolac tromethamine. The differences between ROP stagings were not significant even when analyzed by GA and BW subgroups. No significant treatment-related side effects occurred. CONCLUSION:This report suggests that ketorolac tromethamine ophthalmic solution cannot reduce the risk of developing severe ROP in preterm infants.
Inglese
Giannantonio, C., Papacci, P., Purcaro, V., Cota, F., Tesfagabir, G., Molle, F., Lepore, D., Baldascino, A., Romagnoli, C., Effectiveness of Ketorolac Tromethamine in Prevention of Severe Retinopathy of Prematurity., <>, 2010; (Settembre): 1-5 [http://hdl.handle.net/10807/23113]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/23113
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