Patients with COVID-19 show a high prevalence of liver injury. The pattern of this liver damage is still not fully understood. Different etiopathogenetic factors may concur; from a direct cytopathic effect, once the virus binds to the ACE-2 receptors, to the immune-mediated collateral damage, due to cytokine storm. The presence of pre-existing chronic liver disease is a contributing factor for acute organ damage during SARS-CoV2 infection. Last but not least, treatments probably play a role, also, in determining hepatotoxicity: many of the drugs we have used or are still using to treat COVID-19, combined with non-invasive ventilation, are known to sometimes determine acute liver injury. Although liver damage associated with COVID-19 is often transient and can resolve without any special treatment, it is important to understand the underlying mechanisms, particularly to better treat its more severe forms.

Gabrielli, M., Franza, L., Esperide, A., Gasparrini, I., Gasbarrini, A., Franceschi, F., On Behalf Of Gemelli Against Covid, N., Liver Injury in Patients Hospitalized for COVID-19: Possible Role of Therapy, <<VACCINES>>, N/A; 10 (2): 192-N/A. [doi:10.3390/vaccines10020192] [https://hdl.handle.net/10807/230898]

Liver Injury in Patients Hospitalized for COVID-19: Possible Role of Therapy

Gabrielli, Maurizio;Franza, Laura;Esperide, Alessandra;Gasparrini, Irene;Gasbarrini, Antonio;Franceschi, Francesco;
2022

Abstract

Patients with COVID-19 show a high prevalence of liver injury. The pattern of this liver damage is still not fully understood. Different etiopathogenetic factors may concur; from a direct cytopathic effect, once the virus binds to the ACE-2 receptors, to the immune-mediated collateral damage, due to cytokine storm. The presence of pre-existing chronic liver disease is a contributing factor for acute organ damage during SARS-CoV2 infection. Last but not least, treatments probably play a role, also, in determining hepatotoxicity: many of the drugs we have used or are still using to treat COVID-19, combined with non-invasive ventilation, are known to sometimes determine acute liver injury. Although liver damage associated with COVID-19 is often transient and can resolve without any special treatment, it is important to understand the underlying mechanisms, particularly to better treat its more severe forms.
2022
Inglese
Gabrielli, M., Franza, L., Esperide, A., Gasparrini, I., Gasbarrini, A., Franceschi, F., On Behalf Of Gemelli Against Covid, N., Liver Injury in Patients Hospitalized for COVID-19: Possible Role of Therapy, <<VACCINES>>, N/A; 10 (2): 192-N/A. [doi:10.3390/vaccines10020192] [https://hdl.handle.net/10807/230898]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/230898
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