Objective: To test the hypothesis claiming an association between human papilloma virus (HPV) sperm infection and idiopathic recurrent pregnancy loss (RPL). Design: Multicenter retrospective case-control study. Setting: Three university hospitals. Patient(s): Cases included men belonging to couples affected by first trimester idiopathic RPL. Controls included men belonging to couples with proven fertility and no history of pregnancy loss; RPL was defined as the previous loss of 2 or more pregnancies. Couples were defined as "fertile" if they achieved a full-term pregnancy within the year before enrollment in the study. All participants conceived without assistance. Main outcome measure(s): The association between HPV DNA sperm infection, as identified using polymerase chain reaction, and RPL. Results: The HPV DNA sperm infection was detected in 23 of 117 cases (20%; 95% confidence interval [CI]: 13%, 28%) and in 3 of 84 controls (4%; 95% CI; 1%, 10%) (P<.001). A comparison across baseline characteristics and multiple regression analysis did not identify any potentially confounding factors. Multivariate regression models showed a significant association between HPV DNA sperm infection and RPL (adjusted odds ratio, 7.44; 95% CI: 2.08, 26.58; P=.002 [Model 1]; adjusted odds ratio, 8.96; 95% CI: 2.41, 33.44; P=.001 [Model 2]). Conclusions: The prevalence of HPV sperm infection was significantly higher in couples affected by RPL than in their fertile counterparts. Notably, the semen sample was infected by HPV in approximately 1 out of 5 patients.

Busnelli, A., Garolla, A., Tersigni, C., Parodi, V., Inversetti, A., Levi-Setti, P. E., Scambia, G., Di Simone, N., Sperm human papillomavirus infection and risk of idiopathic recurrent pregnancy loss: insights from a multicenter case-control study, <<FERTILITY AND STERILITY>>, 2023; 119 (3): 410-418. [doi:10.1016/j.fertnstert.2022.12.002] [https://hdl.handle.net/10807/230635]

Sperm human papillomavirus infection and risk of idiopathic recurrent pregnancy loss: insights from a multicenter case-control study

Tersigni, Chiara;Scambia, Giovanni;Di Simone, Nicoletta
2023

Abstract

Objective: To test the hypothesis claiming an association between human papilloma virus (HPV) sperm infection and idiopathic recurrent pregnancy loss (RPL). Design: Multicenter retrospective case-control study. Setting: Three university hospitals. Patient(s): Cases included men belonging to couples affected by first trimester idiopathic RPL. Controls included men belonging to couples with proven fertility and no history of pregnancy loss; RPL was defined as the previous loss of 2 or more pregnancies. Couples were defined as "fertile" if they achieved a full-term pregnancy within the year before enrollment in the study. All participants conceived without assistance. Main outcome measure(s): The association between HPV DNA sperm infection, as identified using polymerase chain reaction, and RPL. Results: The HPV DNA sperm infection was detected in 23 of 117 cases (20%; 95% confidence interval [CI]: 13%, 28%) and in 3 of 84 controls (4%; 95% CI; 1%, 10%) (P<.001). A comparison across baseline characteristics and multiple regression analysis did not identify any potentially confounding factors. Multivariate regression models showed a significant association between HPV DNA sperm infection and RPL (adjusted odds ratio, 7.44; 95% CI: 2.08, 26.58; P=.002 [Model 1]; adjusted odds ratio, 8.96; 95% CI: 2.41, 33.44; P=.001 [Model 2]). Conclusions: The prevalence of HPV sperm infection was significantly higher in couples affected by RPL than in their fertile counterparts. Notably, the semen sample was infected by HPV in approximately 1 out of 5 patients.
2023
Inglese
Busnelli, A., Garolla, A., Tersigni, C., Parodi, V., Inversetti, A., Levi-Setti, P. E., Scambia, G., Di Simone, N., Sperm human papillomavirus infection and risk of idiopathic recurrent pregnancy loss: insights from a multicenter case-control study, <<FERTILITY AND STERILITY>>, 2023; 119 (3): 410-418. [doi:10.1016/j.fertnstert.2022.12.002] [https://hdl.handle.net/10807/230635]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/230635
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