Introduction: In the last decades, many medications have been tested for the treatment of Alcohol Use Disorder (AUD). Among them, disulfiram, acamprosate, naltrexone, nalmefene, sodium oxybate and baclofen have been approved in different countries, with different specific indications. Topiramate is not approved for the treatment of AUD, however, it is suggested as a therapeutic option by the American Psychiatric Association for patients who do not tolerate or respond to approved therapies.Areas covered: In this narrative review we have analyzed the main studies available in literature, investigating the efficacy and safety of these medications, distinguishing whether they were oriented towards abstinence or not. Randomized controlled studies, analyzing larger populations for longer periods were the main focus of our analysis.Conclusions: The medications currently available for the treatment of AUD are quite effective, yet further progress can still be achieved through the personalized strategies. Also, these medications are still markedly underutilized in clinical practice and many patients do not have access to specialized treatment.

Antonelli, M., Sestito, L., Tarli, C., Addolorato, G., Perspectives on the pharmacological management of alcohol use disorder: Are the approved medications effective?, <<EUROPEAN JOURNAL OF INTERNAL MEDICINE>>, 2022; 103 (settembre): 13-22. [doi:10.1016/j.ejim.2022.05.016] [https://hdl.handle.net/10807/230549]

Perspectives on the pharmacological management of alcohol use disorder: Are the approved medications effective?

Sestito, Luisa;Tarli, Claudia;Addolorato, Giovanni
2022

Abstract

Introduction: In the last decades, many medications have been tested for the treatment of Alcohol Use Disorder (AUD). Among them, disulfiram, acamprosate, naltrexone, nalmefene, sodium oxybate and baclofen have been approved in different countries, with different specific indications. Topiramate is not approved for the treatment of AUD, however, it is suggested as a therapeutic option by the American Psychiatric Association for patients who do not tolerate or respond to approved therapies.Areas covered: In this narrative review we have analyzed the main studies available in literature, investigating the efficacy and safety of these medications, distinguishing whether they were oriented towards abstinence or not. Randomized controlled studies, analyzing larger populations for longer periods were the main focus of our analysis.Conclusions: The medications currently available for the treatment of AUD are quite effective, yet further progress can still be achieved through the personalized strategies. Also, these medications are still markedly underutilized in clinical practice and many patients do not have access to specialized treatment.
2022
Inglese
Antonelli, M., Sestito, L., Tarli, C., Addolorato, G., Perspectives on the pharmacological management of alcohol use disorder: Are the approved medications effective?, <<EUROPEAN JOURNAL OF INTERNAL MEDICINE>>, 2022; 103 (settembre): 13-22. [doi:10.1016/j.ejim.2022.05.016] [https://hdl.handle.net/10807/230549]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/230549
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact