Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors.In this paper, we will review data of TME and target therapies in somatotropinomas.
Chiloiro, S., De Marinis Grasso, L., The immune microenviroment in somatotropinomas: from biology to personalized and target therapy, <<REVIEWS IN ENDOCRINE & METABOLIC DISORDERS>>, 2023; (2): 283-295. [doi:10.1007/s11154-022-09782-1] [https://hdl.handle.net/10807/230208]
The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
Chiloiro, SabrinaPrimo
Writing – Original Draft Preparation
;De Marinis Grasso, Laura
Ultimo
Writing – Review & Editing
2023
Abstract
Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors.In this paper, we will review data of TME and target therapies in somatotropinomas.File | Dimensione | Formato | |
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