Background: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences. Main body: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells. Conclusion: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.

Caforio, M., Sorino, C., Iacovelli, S., Fanciulli, M., Locatelli, F., Folgiero, V., Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis, <<JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH>>, 2018; 37 (1): 1-9. [doi:10.1186/s13046-018-0912-2] [https://hdl.handle.net/10807/229948]

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Locatelli, Franco
Penultimo
Writing – Review & Editing
;
2018

Abstract

Background: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences. Main body: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells. Conclusion: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.
2018
Inglese
Caforio, M., Sorino, C., Iacovelli, S., Fanciulli, M., Locatelli, F., Folgiero, V., Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis, <<JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH>>, 2018; 37 (1): 1-9. [doi:10.1186/s13046-018-0912-2] [https://hdl.handle.net/10807/229948]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/229948
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 40
social impact